Role of Snail family proteins in male fertility and testicular cancer
Grant number: 1048110 | Funding period: 2013 - 2016
Male fertility requires production of healthy sperm in the testis. This project builds on our discoveries that testicular cells regulate gene activity via the Snail family of proteins during sperm development, and that interruption of their activities reduces fertility in mice and fruitflies. Snail proteins are also active in cancer cells. We propose to study the precise steps in sperm production affected by Snail proteins and how they affect the progression of testicular cancer.
Related publications (4)
'Snail factors in testicular germ cell tumours and their regulation by the BMP4 signalling pathway'
Diana J Micati, Karthika Radhakrishnan, Julia C Young, Ewa Rajpert-De Meyts, Gary R Hime, Helen E Abud, Kate L Loveland
BACKGROUND: Snail transcription factors mediate key cellular transitions in many developmental processes, including spermatogenesi..
Rbf Regulates Drosophila Spermatogenesis via Control of Somatic Stem and Progenitor Cell Fate in the Larval Testis
Nicole Dominado, John E La Marca, Nicole A Siddall, James Heaney, Mai Tran, Yu Cai, Fengwei Yu, Hongyan Wang, W Gregory Somers, Leonie M Quinn, Gary R Hime
The Drosophila testis has been fundamental to understanding how stem cells interact with their endogenous microenvironment, or nic..
Microarray profiling to analyze the effect of Snai1 loss in mouse intestinal epithelium
Gary R Hime, Katja Horvay, Thierry Jarde, Franca Casagranda, Victoria M Perreau, Helen E Abud
Epithelial stem cells from a variety of tissues have been shown to express genes linked to mesenchymal cell states. The Snail fami..