P2X7 mediated phagocytosis of apoptotic cells: a common mechanism underlies neurological and eye disorders

Grant number: 1048082 | Funding period: 2013 - 2015

Completed

Abstract

We have found a strong genetic linkage between a protein called P2X7 and a number of neurological disorders, in line with our recent discovery of a novel function of this protein in clearance of dying cells as removal of unhealthy neurons is essential to keep brain function promptly. Further study using genetic association, cell biology and animal models will lead to a conceptual advance on how neurological diseases are occurred and developed.