P2X7 mediated phagocytosis of apoptotic cells: a common mechanism underlies neurological and eye disorders

Grant number: 1048082 | Funding period: 2013 - 2015

Completed

Abstract

We have found a strong genetic linkage between a protein called P2X7 and a number of neurological disorders, in line with our recent discovery of a novel function of this protein in clearance of dying cells as removal of unhealthy neurons is essential to keep brain function promptly. Further study using genetic association, cell biology and animal models will lead to a conceptual advance on how neurological diseases are occurred and developed.

Related publications (11)

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P2X7 IS AN ARCHAIC SCAVENGER RECEPTOR RECOGNIZING APOPTOTIC NEUROBLASTS IN EARLY HUMAN NEUROGENESIS

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Deficits in Monocyte Function in Age Related Macular Degeneration: A Novel Systemic Change Associated With the Disease

Ben J Gu, Xin Huang, Pavan K Avula, Emily Caruso, Candace Drysdale, Kirstan A Vessey, Amber Ou, Christopher Fowler, Tian-Hua Liu, Yong Lin, Adam Horton, Colin L Masters, James S Wiley, Robyn H Guymer, Erica L Fletcher

2021-03-17

Age-related macular degeneration (AMD) is characterized by the accumulation of debris in the posterior eye. In this study we evalu..

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P2X7 Receptors Regulate Phagocytosis and Proliferation in Adult Hippocampal and SVZ Neural Progenitor Cells: Implications for Inflammation in Neurogenesis

Hannah C Leeson, Maria A Kasherman, Tailoi Chan-Ling, Michael D Lovelace, Jeremy C Brownlie, Kelly M Toppinen, Ben J Gu, Michael W Weible

2018-11-01

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The scavenger activity of the human P2X7 receptor differs from P2X7 pore function by insensitivity to antagonists, genetic variation and sodium concentration: Relevance to inflammatory brain diseases

Amber Ou, Ben J Gu, James S Wiley

2018-04-01

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Purinergic receptors P2RX4 and P2RX7 in familial multiple sclerosis

A Dessa Sadovnick, Ben J Gu, Anthony L Traboulsee, Cecily Q Bernales, Mary Encarnacion, Irene M Yee, Maria G Criscuoli, Xin Huang, Amber Ou, Carol J Milligan, Steven Petrou, James S Wiley, Carles Vilarino-Guell

2017-06-01

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Innate phagocytosis by peripheral blood monocytes is altered in Alzheimer's disease

Ben J Gu, Xin Huang, Amber Ou, Alan Rembach, Christopher Fowler, Pavan K Avula, Adam Horton, James D Doecke, Victor L Villemagne, S Lance Macaulay, Paul Maruff, Erica L Fletcher, Robyn Guymer, James S Wiley, Colin L Masters

2016-09-01

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A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis

Ben J Gu, Judith Field, Sebastien Dutertre, Amber Ou, Trevor J Kilpatrick, Jeannette Lechner-Scott, Rodney Scott, Rodney Lea, Bruce V Taylor, Jim Stankovich, Helmut Butzkueven, Melissa Gresle, Simon M Laws, Steven Petrou, Sabine Hoffjan, Denis A Akkad, Colin A Graham, Stanley Hawkins, Anna Glaser, Sahl Khalid Bedri

2015-10-01

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Shear stress modulates endothelial KLF2 through activation of P2X4

R Sathanoori, F Rosi, BJ Gu, JS Wiley, CE Mueller, B Olde, D Erlinge

2015-03-01

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P2X7 Receptors Mediate Innate Phagocytosis by Human Neural Precursor Cells and Neuroblasts

Michael D Lovelace, Ben J Gu, Steven S Eamegdool, Michael W Weible, James S Wiley, David G Allen, Tailoi Chan-Ling

2015-02-01

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A Quantitative Method for Measuring Innate Phagocytosis by Human Monocytes Using Real-Time Flow Cytometry

Ben J Gu, Chun Sun, Stephen Fuller, Kristen K Skarratt, Steven Petrou, James S Wiley

2014-04-01

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A rare functional haplotype of the P2RX4 and P2RX7 genes leads to loss of innate phagocytosis and confers increased risk of age-related macular degeneration

Ben J Gu, Paul N Baird, Kirstan A Vessey, Kristen K Skarratt, Erica L Fletcher, Stephen J Fuller, Andrea J Richardson, Robyn H Guymer, James S Wiley

2013-04-01