Cellular Contributions to PAR-2's Essential Role in Periodontal Disease

Grant number: 1044103 | Funding period: 2013 - 2017

Completed

Abstract

Periodontal disease is a disease of the gums, which ultimately causes loss of teeth. It is a debilitating condition affecting about 20% of Australian adults. PAR-2, a receptor for protein-degrading enzymes, which is present on cells in the gums, is known to be required for development of the disease. This project will investigate the mechanism of PAR-2’s involvement in periodontal disease and provide ideas for development of treatments.

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University of Melbourne Researchers

Eleanor Mackie

Charles Pagel