New High Thoughput Animal Models To Investigate Amyloid Beta Toxicity

Abstract

Amyloid-beta is widely considered to cause Alzheimer’s disease. The majority of amyloid-beta in Alzheimer's disease brains is found as shortened forms. The role of these shortened forms is uncertain and are not being tested in current animal models. We propose to develop new models to determine and compare their respective toxic effects, and to use these new models to help identify drugs to treat Alzheimer's disease.