Muscarinic receptors in the human brain: In health and in sickness

Muscarinic receptor binding changes in postmortem Parkinson's disease

Caitlin McOmish, Geoff Pavey, Catriona McLean, Malcolm Horne, Brian Dean, Elizabeth Scarr

2017-02-01

Parkinson's disease (PD) is a devastating disorder, affecting approximately 2% of people aged 60 and above. It is marked by progre..

Evidence for impaired glucose metabolism in the striatum, obtained postmortem, from some subjects with schizophrenia

B Dean, N Thomas, E Scarr, M Udawela

2016-11-15

Studies using central nervous system tissue obtained postmortem suggest pathways involved in energy and metabolism contribute to t..

The distribution of muscarinic M1 receptors in the human hippocampus

Elizabeth Scarr, Myoung Suk Seo, Timothy Douglas Aumann, Gursharan Chana, Ian Paul Everall, Brian Dean

2016-11-01

The muscarinic M1 receptor plays a significant role in cognition, probably by modulating information processing in key regions suc..

Understanding the pathophysiology of schizophrenia: Contributions from the Melbourne Psychiatric Brain Bank

Brian Dean, David Copolov, Elizabeth Scarr

2016-11-01

The Melbourne Psychiatric Brain Bank came into existence 25years ago. This review focusses on lines of research that have used tis..

COMT genotype is associated with differential expression of muscarinic M1 receptors in human cortex

Brian Dean, Elizabeth Scarr

2016-09-01

Catechol-O-methyltransferase (COMT) genotype has been associated with varying levels of cognitive functioning and an altered risk ..

Validating reference genes using minimally transformed qpcr data: findings in human cortex and outcomes in schizophrenia

Brian Dean, Madhara Udawela, Elizabeth Scarr

2016-05-20

BACKGROUND: It is common practice, when using quantitative real time polymerase chain reaction (qPCR), to normalise levels of mRNA..

Changes in BQCA Allosteric Modulation of [H-3]NMS Binding to Human Cortex within Schizophrenia and by Divalent Cations

Brian Dean, Shaun Hopper, P Jeffrey Conn, Elizabeth Scarr

2016-05-01

Stimulation of the cortical muscarinic M1 receptor (CHRM1) is proposed as a treatment for schizophrenia, a hypothesis testable usi..

Lower [3H]LY341495 binding to mGlu2/3 receptors in the anterior cingulate of subjects with major depressive disorder but not bipolar disorder or schizophrenia

Caitlin E McOmish, Geoff Pavey, Andrew Gibbons, Shaun Hopper, Madhara Udawela, Elizabeth Scarr, Brian Dean

2016-01-15

INTRODUCTION: The glutamatergic system has recently been implicated in the pathogenesis and treatment of major depressive disorder..

Changes in cholinergic and glutamatergic markers in the striatum from a sub-set of subjects with schizophrenia

Brian Dean, Natalie Thomas, Chi-Yu Lai, Wei J Chen, Elizabeth Scarr

2015-12-01

BACKGROUND/OBJECTIVES: Having separated a sub-group of people with schizophrenia based on a marked loss of cortical [(3)H]pirenzep..

The Role of Muscarinic Receptors in the Pathophysiology of Mood Disorders: A Potential Novel Treatment?

Won Je Jeon, Brian Dean, Elizabeth Scarr, Andrew Gibbons

2015-01-01

The central cholinergic system has been implicated in the pathophysiology of mood disorders. An imbalance in central cholinergic n..

Potential Molecular and Cellular Mechanism of Psychotropic Drugs

Myoung Suk Seo, Elizabeth Scarr, Chi-Yu Lai, Brian Dean

2014-08-01

Psychiatric disorders are among the most debilitating of all medical illnesses. Whilst there are drugs that can be used to treat t..