Viewing the cellular responses in Huntington's disease through an aggreomics framework

Grant number: 1049458 | Funding period: 2013 - 2016

Completed

Abstract

Huntington disease results from a mutation that causes the Htt protein to form abnormal toxic clusters in neurons that eventually leads to cell death. This project will develop and apply new technology to identify how the clustering process damages cells and will measure all the gene expression changes that occur during the clustering process. The project offers much potential for revealing new therapeutic targets to this incurable disease.

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