Understanding the Role of the Essential Regulator WalKR in Staphylococcus Aureus

Grant number: 1049192 | Funding period: 2013 - 2015

Completed

Abstract

Staphylococcus aureus is one of the most common human bacterial pathogens. This project aims to characterise an important global control system in S. aureus, and determine if chemical inhibitors of this control system could be used to treat S. aureus disease in the future.

Related publications (2)

Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus

IR Monk, N Shaikh, SL Begg, M Gajdiss, LKR Sharkey, JYH Lee, SJ Pidot, T Seemann, M Kuiper, B Winnen, R Hvorup, BM Collins, G Bierbaum, SR Udagedara, JR Morey, N Pulyani, BP Howden, MJ Maher, CA McDevitt, GF King

2019-12-01

WalKR (YycFG) is the only essential two-component regulator in the human pathogen Staphylococcus aureus. WalKR regulates peptidogl..

Correspondence: Spontaneous secondary mutations confound analysis of the essential two-component system WalKR in Staphylococcus aureus

IR Monk, BP Howden, T Seemann, TP Stinear

2017-02-06

University of Melbourne Researchers

Tim Stinear

Ben Howden