Mechanisms of respiratory virus induced pneumococcal infection in the middle ear.
Grant number: 1044976 | Funding period: 2013 - 2016
Streptococcus pneumoniae (the pneumococcus) is a common bacterium that temporarily lives in the nose of most young children, usually not causing any disease. Predisposing conditions, such as infection with a respiratory virus, may result in development of clinical disease. We will investigate how influenza virus mediates inflammation of the middle ear (otitis media) leading to pneumococcal infection. In particular, modulation of the middle ear innate immune response by viral protein will be studied.
Related publications (3)
Unique Transcriptional Architecture in Airway Epithelial Cells and Macrophages Shapes Distinct Responses following Influenza Virus Infection Ex Vivo
Joel Z Ma, Wy Ching Ng, Luke Zappia, Linden J Gearing, Moshe Olshansky, Kym Pham, Karey Cheong, Arthur Hsu, Stephen J Turner, Odilia Wijburg, Sarah L Londrigan, Andrew G Brooks, Patrick C Reading
Airway epithelial cells and macrophages differ markedly in their responses to influenza A virus (IAV) infection. To investigate tr..
Host Cell Restriction Factors that Limit Influenza A Infection
Fernando Villalon-Letelier, Andrew G Brooks, Philippa M Saunders, Sarah L Londrigan, Patrick C Reading
Viral infection of different cell types induces a unique spectrum of host defence genes, including interferon-stimulated genes (IS..
Antibodies Mediate Formation of Neutrophil Extracellular Traps in the Middle Ear and Facilitate Secondary Pneumococcal Otitis Media
Kirsty R Short, Maren von Koeckritz-Blickwede, Jeroen D Langereis, Keng Yih Chew, Emma R Job, Charles W Armitage, Brandon Hatcher, Kohtaro Fujihashi, Patrick C Reading, Peter W Hermans, Odilia L Wijburg, Dimitri A Diavatopoulos
Otitis media (OM) (a middle ear infection) is a common childhood illness that can leave some children with permanent hearing loss...