A functional in vivo shRNA screen for regulators of breast cancer metastasis.
Grant number: 1050384 | Funding period: 2013 - 2015
Breast cancer is generally incurable if detected after the tumour has spread to other organs. The genes driving the tumour cells to other sites have not been clearly resolved. This project aims to accelerate the discovery process by using a genome wide functional screen to identify genes that control the spread of breast cancer. If successful, this project could lead very quickly to identification of genes that might be good targets for new therapy against advanced breast cancer.
Related publications (3)
Annexin A1 Is Required for Efficient Tumor Initiation and Cancer Stem Cell Maintenance in a Model of Human Breast Cancer
Cameron N Johnstone, Yan Tu, Shenna Langenbach, David Baloyan, Andrew D Pattison, Peter Lock, Kara L Britt, Brian D Lehmann, Traude H Beilharz, Matthias Ernst, Robin L Anderson, Alastair G Stewart
Triple-negative breast cancer (TNBC) has a poor outcome compared to other breast cancer subtypes, and new therapies that target th..
FGF13 promotes metastasis of triple-negative breast cancer
Cameron N Johnstone, Andrew D Pattison, Paul F Harrison, David R Powell, Peter Lock, Matthias Ernst, Robin L Anderson, Traude H Beilharz
Triple-negative breast cancer (TNBC) represents 10-20% of all human ductal adenocarcinomas and has a poor prognosis relative to ot..
Neoadjuvant neratinib promotes ferroptosis and inhibits brain metastasis in a novel syngeneic model of spontaneous HER2( ve) breast cancer metastasis
Aadya Nagpal, Richard P Redvers, Xiawei Ling, Scott Ayton, Miriam Fuentes, Elnaz Tavancheh, Irmina Diala, Alshad Lalani, Sherene Loi, Steven David, Robin L Anderson, Yvonne Smith, Delphine Merino, Delphine Denoyer, Normand Pouliot
BACKGROUND: Human epidermal growth factor receptor-2 (HER2)-targeted therapies prolong survival in HER2-positive breast cancer pat..