AGE-RELATED IMPAIRMENT OF AUTOREGULATION: A MODIFIABLE RISK FACTOR FOR GLAUCOMA

The Effect of Aging on Retinal Function and Retinal Ganglion Cell Morphology Following Intraocular Pressure Elevation

Pei Ying Lee, Da Zhao, Vickie HY Wong, Vicki Chrysostomou, Jonathan G Crowston, Bang V Bui

2022-05-12

Aging and elevated intraocular pressure (IOP) are two major risk factors for glaucomatous optic neuropathy; a condition characteri..

Response of the Rat Optic Nerve to Acute Intraocular and Intracranial Pressure Changes

Da Zhao, Zheng He, Anna Van Koeverden, Algis J Vingrys, Vickie HY Wong, Jeremiah KH Lim, Christine TO Nguyen, Bang V Bui

2019-01-01

Glaucoma is a neurodegenerative disease, characterized by the progressive death of retinal ganglion cells. Elevated intraocular pr..

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice

Z He, D Zhao, AK van Koeverden, CT Nguyen, JKH Lim, VHY Wong, AJ Vingrys, BV Bui

2018-10-01

The circumlimbal suture is a technique for inducing experimental glaucoma in rodents by chronically elevating intraocular pressure..

Response of the trilaminar retinal vessel network to intraocular pressure elevation in rat eyes

Bang V Bui, Da Zhao, Lin Wang, Brad Fortune, Zheng He

2018-07-01

Purpose : It is known that inner retinal blood flow is autoregulated to compensate for changes in ocular perfusion pressure (OPP)...

Systemic hypertension is not protective against chronic intraocular pressure elevation in a rodent model

Anna K van Koeverden, Zheng He, Christine TO Nguyen, Algis J Vingrys, Bang V Bui

2018-05-08

High intraocular pressure is the most well documented glaucoma risk factor; however many patients develop and/or show progression ..

Age-related changes in the response of retinal structure, function and blood flow to pressure modification in rats

Da Zhao, Christine TO Nguyen, Zheng He, Vickie HY Wong, Anna K van Koeverden, Algis J Vingrys, Bang V Bui

2018-02-13

Age-related changes to the balance between the pressure inside the eye (intraocular pressure, IOP) and the pressure inside the bra..

Characterization of the Circumlimbal Suture Model of Chronic IOP Elevation in Mice and Assessment of Changes in Gene Expression of Stretch Sensitive Channels.

Da Zhao, Christine TO Nguyen, Vickie HY Wong, Jeremiah KH Lim, Zheng He, Andrew I Jobling, Erica L Fletcher, Holly R Chinnery, Algis J Vingrys, Bang V Bui

2017-01-10

To consider whether a circumlimbal suture can be used to chronically elevate intraocular pressure (IOP) in mice and to assess its ..

Reversal of functional loss in a rat model of chronic intraocular pressure elevation

Hsin-Hua Liu, Zheng He, Christine TO Nguyen, Algis J Vingrys, Bang V Bui

2017-01-01

PURPOSE: This pilot study considered whether intraocular pressure (IOP) lowering could reverse ganglion cell dysfunction in a rat ..

Early Postnatal Hyperoxia in Mice Leads to Severe Persistent Vitreoretinopathy

Paul G McMenamin, Rachel Kenny, Sjakon Tahija, Jeremiah Lim, Cecilia Naranjo Golborne, Xiangting Chen, Sheena Bouch, Foula Sozo, Bang Bui

2016-12-01

PURPOSE: To describe a mouse model of hyperoxia-induced vitreoretinopathy that replicated some of the clinical and pathologic feat..

Intraocular Pressure Induced Retinal Changes Identified Using Synchrotron Infrared Microscopy

Hsin-Hui Shen, Guei-Sheung Liu, Seong Hoong Chow, Jiang-Hui Wang, Zheng He, Christine Nguyen, Tsung-Wu Lin, Bang V Bui

2016-10-06

Infrared (IR) spectroscopy has been used to quantify chemical and structural characteristics of a wide range of materials includin..

Circumlimbal suture chronic intraocular pressure elevation in mice

Bang V Bui, Da Zhao, Tram Oanh Nguyen Christine, Jeremiah KH Lim, Holly Rose Chinnery, Algis I Vingrys, Zheng He

2016-09-01

Effect of systemic blood pressure modification on ocular and cerebral blood vessels

Shajan Velaedan, Zheng He, Algis J Vingrys, Bang V Bui

2016-09-01

Simultaneous Recording of Electroretinography and Visual Evoked Potentials in Anesthetized Rats

Christine T Nguyen, Tina I Tsai, Zheng He, Algis J Vingrys, Pei Y Lee, Bang V Bui

2016-07-01

The electroretinogram (ERG) and visual evoked potential (VEP) are commonly used to assess the integrity of the visual pathway. The..

The effect of intraocular and intracranial pressure on retinal structure and function in rats

Da Zhao, Zheng He, Algis J Vingrys, Bang V Bui, Christine TO Nguyen

2015-08-01

An increasing number of studies indicate that the optic nerve head of the eye is sensitive not only to changes in intraocular pres..

Provocative intraocular pressure challenge preferentially decreases venous oxygen saturation despite no reduction in blood flow

Rachael A O'Connell, Andrew J Anderson, Sarah L Hosking, Bang V Bui

2015-03-01

PURPOSE: Ocular disease can both alter the retina's oxygen requirements, and decrease its ability to cope with changes in metaboli..

Chronic Hypertension Increases Susceptibility to Acute IOP Challenge in Rats

Zheng He, Algis J Vingrys, James A Armitage, Christine T Nguyen, Bang V Bui

2014-12-01

PURPOSE: To consider the effect of chronic arterial hypertension on the susceptibility of the retina to acute IOP challenge. METHO..

Effect of Acute Intraocular Pressure Challenge on Rat Retinal and Cortical Function

Tina I Tsai, Bang V Bui, Algis J Vingrys

2014-02-01

PURPOSE: The global or gross response index of visual performance measured from the eye does not necessarily translate to global r..

Relationship between the Magnitude of Intraocular Pressure during an Episode of Acute Elevation and Retinal Damage Four Weeks later in Rats

Bang V Bui, Abrez H Batcha, Erica Fletcher, Vickie HY Wong, Brad Fortune

2013-07-29

PURPOSE: To determine relationship between the magnitude of intraocular pressure (IOP) during a fixed-duration episode of acute el..

Sustained and Transient Contributions to the Rat Dark-Adapted Electroretinogram b-Wave

Trung M Dang, Algis J Vingrys, Bang V Bui

2013-01-01

The most dominant feature of the electroretinogram, the b-wave, is thought to reflect ON-bipolar cell responses. However, a number..