Targeting small airways to overcome resistance to therapy in asthma
Grant number: 1041575 | Funding period: 2013 - 2014
There is a pressing need to overcome resistance to current therapies for severe asthma. Targetting inflammation-induced changes in small airway contraction offers an alternative strategy. We have identified a novel bronchodilator that relaxes maximally contracted mouse small airways when current treatment is ineffective. We will demonstrate its efficacy in animal models mimicking key features of human asthma, and define new ways to improve outcomes in poorly-controlled asthma.
Related publications (5)
Influenza A virus infection and cigarette smoke impair bronchodilator responsiveness to beta-adrenoceptor agonists in mouse lung
Chantal Donovan, Huei Jiunn Seow, Jane E Bourke, Ross Vlahos
β2-adrenoceptor agonists are the mainstay therapy for patients with asthma but their effectiveness in cigarette smoke (CS)-induced..
Rosiglitazone elicits in vitro relaxation in airways and precision cut lung slices from a mouse model of chronic allergic airways disease
Chantal Donovan, Simon R Bailey, Jenny Tran, Gertruud Haitsma, Zaridatul A Ibrahim, Simon R Foster, Mimi LK Tang, Simon G Royce, Jane E Bourke
Rosiglitazone (RGZ), a peroxisome proliferator-activated receptor-γ (PPARγ) ligand, is a novel dilator of small airways in mouse p..
Alteration of Airway Reactivity and Reduction of Ryanodine Receptor Expression by Cigarette Smoke in Mice
Chantal Donovan, Huei Jiunn Seow, Simon G Royce, Jane E Bourke, Ross Vlahos
Small airways are a major site of airflow limitation in chronic obstructive pulmonary disease (COPD). Despite the detrimental effe..
Differential Effects of Allergen Challenge on Large and Small Airway Reactivity in Mice
Chantal Donovan, Simon G Royce, James Esposito, Jenny Tran, Zaridatul Aini Ibrahim, Mimi LK Tang, Simon Bailey, Jane E Bourke
The relative contributions of large and small airways to hyperresponsiveness in asthma have yet to be fully assessed. This study u..