Determinants of CTL recruitment into the immune response

Grant number: 1046333 | Funding period: 2013 - 2015

Completed

Abstract

The size of CD8+ T cell (CTL) responses is central to their efficacy in virus control, and can be substantially influenced by how effectively they are recruited and expand after infection. This study will determine the impact of both CTL characteristics and antigen abundance on CTL recruitment and expansion after infection. Understanding the nature of these influences will enable a more informed approach to the clinical manipulation of CTL responses.

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