NUTRACEUTICALS IN THE TREATMENT OF DEPRESSION

Grant number: 1048222 | Funding period: 2013 - 2017

Completed

Abstract

An emerging approach to treat depression is via the use of adjunctive nutraceuticals (nutrient-based natural products). Specific antidepressant nutraceuticals can target a range of key neurological pathways that can treat depression. We are conducting an 8 week clinical trial comparing the efficacy of a range of nutraceuticals- such as folic acid, omega-3, and zinc, in adults with depression who are non-responsive to current pharmaceutical antidepressants.

Related publications (7)

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EPA and DHA as markers of nutraceutical treatment response in major depressive disorder

Kiki P van der Burg, Lachlan Cribb, Joseph Firth, Diana Karmacoska, David Mischoulon, Gerard J Byrne, Chad Bousman, Con Stough, Jenifer Murphy, Georgina Oliver, Michael Berk, Chee H Ng, Jerome Sarris

2020-09-01

PURPOSE: Depression clinical trials are increasingly studying biomarkers to predict and monitor response to treatment. Assessment ..

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S-Adenosylmethionine (SAMe) monotherapy for depression: an 8-week double-blind, randomised, controlled trial

Jerome Sarris, Jenifer Murphy, Con Stough, David Mischoulon, Chad Bousman, Patricia MacDonald, Laura Adams, Sonia Nazareth, Georgina Oliver, Lachlan Cribb, Karen Savage, Ranjit Menon, Suneel Chamoli, Michael Berk, Chee H Ng, Gerard J Byrne

2019-11-11

RATIONALE: Dysregulation of the one carbon cycle is documented in depression. Thereby, S-adenosylmethionine (SAMe), a one-carbon c..

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The relationship between dietary quality, serum brain-derived neurotrophic factor (BDNF) level, and the Val66met polymorphism in predicting depression

Amy Froud, Jenifer Murphy, Lachlan Cribb, Chee H Ng, Jerome Sarris

2019-07-03

BACKGROUND: Brain-derived neurotrophic factor (BDNF), a neurotrophic factor implicated in the pathogenesis of depression, may be i..

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Nutraceuticals for major depressive disorder- more is not merrier: An 8-week double-blind, randomised, controlled trial

Jerome Sarris, Gerard J Byrne, Con Stough, Chad Bousman, David Mischoulon, Jenifer Murphy, Patricia Macdonald, Laura Adams, Sonia Nazareth, Georgina Oliver, Lachlan Cribb, Karen Savage, Ranjit Menon, Suneel Chamoli, Michael Berk, Chee H Ng

2019-02-15

BACKGROUND: One of the most pressing questions in "Nutritional Psychiatry" is whether using combinations of different nutraceutica..

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Adjunctive S-adenosylmethionine (SAMe) in treating non-remittent major depressive disorder: An 8-week double-blind, randomized, controlled trial

Jerome Sarris, Gerard J Byrne, Chad Bousman, Con Stough, Jenifer Murphy, Patricia MacDonald, Laura Adams, Sonia Nazareth, Georgina Oliver, Lachlan Cribb, Karen Savage, Ranjit Menon, Suneel Chamoli, Michael Berk, Chee Ng, David Mischoulon

2018-10-01

There has been increasing interest in nutraceutical augmentation strategies to boost the efficacy of antidepressants. This study a..

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Erythrocyte polyunsaturated fatty acid composition is associated with depression and FADS genotype in Caucasians

Lachlan Cribb, Jenifer Murphy, Amy Froud, Georgina Oliver, Chad A Bousman, Chee H Ng, Jerome Sarris

2018-01-01

BACKGROUND: Polyunsaturated fatty acids (PUFAs) play an important role in the pathophysiology of major depressive disorder (MDD), ..

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An adjunctive antidepressant nutraceutical combination in treating major depression: Study protocol, and clinical considerations

Jerome Sarris, Con Stough, Chad Bousman, Jenifer Murphy, Karen Savage, Deidre J Smith, Ranjit Menon, Suneel Chamoli, Georgina Oliver, Michael Berk, Gerard J Byrne, Chee Ng, David Mischoulon

2015-04-01

Current treatment for major depressive disorder (MDD), a prevalent and disabling mental illness, is inadequate, with two-thirds of..

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