TESTOSTERONE FOR THE PREVENTION OF DIABETES MELLITUS IN HIGH RISK MEN: A RANDOMISED TRIAL
Grant number: 1030123 | Funding period: 2012 - 2017
Type 2 diabetes (T2DM) is increasingly common, costly and deadly. Some men at risk of T2DM have low testosterone (T) levels. Our preliminary data suggests that T treatment may prevent the development of T2DM, and improve cardiovascular and sexual function, body composition and bone density, and mood. This remains to be fully tested in a randomized placebo-controlled trial, and this project will do so in a 2-year study of T treatment compared to placebo in men at risk of T2DM participating in a lifestyle program.
Related publications (6)
Recovery of male reproductive endocrine function after ceasing prolonged testosterone undecanoate injections
David J Handelsman, Reena Desai, Ann J Conway, Nandini Shankara-Narayana, Bronwyn GA Stuckey, Warrick J Inder, Mathis Grossmann, Bu Beng Yeap, David Jesudason, Lam P Ly, Karen Bracken, Gary Allen Wittert
CONTEXT: The time course of male reproductive hormone recovery after stopping injectable testosterone undecanoate (TU) treatment i..
Effect of Testosterone Treatment on Bone Microarchitecture and Bone Mineral Density in Men: A 2-Year RCT
Mark Ng Tang Fui, Rudolf Hoermann, Karen Bracken, David J Handelsman, Warrick J Inder, Bronwyn GA Stuckey, Bu B Yeap, Ali Ghasem-Zadeh, Kristy P Robledo, David Jesudason, Jeffrey D Zajac, Gary A Wittert, Mathis Grossmann
CONTEXT: Testosterone treatment increases bone mineral density (BMD) in hypogonadal men. Effects on bone microarchitecture, a dete..
Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): a randomised, double-blind, placebo-controlled, 2-year, phase 3b trial
Gary Wittert, Karen Bracken, Kristy P Robledo, Mathis Grossmann, Bu B Yeap, David J Handelsman, Bronwyn Stuckey, Ann Conway, Warrick Inder, Robert McLachlan, Carolyn Allan, David Jesudason, Mark Ng Tang Fui, Wendy Hague, Alicia Jenkins, Mark Daniel, Val Gebski, Anthony Keech
BACKGROUND: Men who are overweight or obese frequently have low serum testosterone concentrations, which are associated with incre..
Telephone call reminders did not increase screening uptake more than SMS reminders: a recruitment study within a trial
Karen Bracken, Anthony Keech, Wendy Hague, Adrienne Kirby, Kristy P Robledo, Carolyn Allan, Ann Conway, Mark Daniel, Val Gebski, Mathis Grossmann, David J Handelsman, Warrick Inder, Alicia Jenkins, Robert McLachlan, Bronwyn Stuckey, Bu B Yeap, Gary Wittert
OBJECTIVES: The aim of the study was to compare the response rates and costs of phone call vs. short message service (SMS) screeni..
Testosterone therapy to prevent type 2 diabetes mellitus in at-risk men (T4DM): Design and implementation of a double-blind randomized controlled trial
Gary Wittert, Evan Atlantis, Carolyn Allan, Karen Bracken, Ann Conway, Mark Daniel, Val Gebski, Mathis Grossmann, Wendy Hague, David J Handelsman, Warrick Inder, Alicia Jenkins, Anthony Keech, Robert McLachlan, Kristy Robledo, Bronwyn Stuckey, Bu B Yeap
BACKGROUND: Low circulating testosterone is associated with an increased risk of developing type 2 diabetes (T2DM) in overweight m..
Testosterone treatment in older men: clinical implications and unresolved questions from the Testosterone Trials
Bu B Yeap, Stephanie T Page, Mathis Grossmann
A decrease in the concentration of circulating testosterone in many older men is a biomarker and possibly a rectifiable contributi..