TESTOSTERONE FOR THE PREVENTION OF DIABETES MELLITUS IN HIGH RISK MEN: A RANDOMISED TRIAL

Grant number: 1030123 | Funding period: 2012 - 2017

Completed

Abstract

Type 2 diabetes (T2DM) is increasingly common, costly and deadly. Some men at risk of T2DM have low testosterone (T) levels. Our preliminary data suggests that T treatment may prevent the development of T2DM, and improve cardiovascular and sexual function, body composition and bone density, and mood. This remains to be fully tested in a randomized placebo-controlled trial, and this project will do so in a 2-year study of T treatment compared to placebo in men at risk of T2DM participating in a lifestyle program.

Related publications (6)

Scholarly works icon

Recovery of male reproductive endocrine function after ceasing prolonged testosterone undecanoate injections

David J Handelsman, Reena Desai, Ann J Conway, Nandini Shankara-Narayana, Bronwyn GA Stuckey, Warrick J Inder, Mathis Grossmann, Bu Beng Yeap, David Jesudason, Lam P Ly, Karen Bracken, Gary Allen Wittert

2022-03-01

CONTEXT: The time course of male reproductive hormone recovery after stopping injectable testosterone undecanoate (TU) treatment i..

Scholarly works icon

Effect of Testosterone Treatment on Bone Microarchitecture and Bone Mineral Density in Men: A 2-Year RCT

Mark Ng Tang Fui, Rudolf Hoermann, Karen Bracken, David J Handelsman, Warrick J Inder, Bronwyn GA Stuckey, Bu B Yeap, Ali Ghasem-Zadeh, Kristy P Robledo, David Jesudason, Jeffrey D Zajac, Gary A Wittert, Mathis Grossmann

2021-07-13

CONTEXT: Testosterone treatment increases bone mineral density (BMD) in hypogonadal men. Effects on bone microarchitecture, a dete..

Scholarly works icon

Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): a randomised, double-blind, placebo-controlled, 2-year, phase 3b trial

Gary Wittert, Karen Bracken, Kristy P Robledo, Mathis Grossmann, Bu B Yeap, David J Handelsman, Bronwyn Stuckey, Ann Conway, Warrick Inder, Robert McLachlan, Carolyn Allan, David Jesudason, Mark Ng Tang Fui, Wendy Hague, Alicia Jenkins, Mark Daniel, Val Gebski, Anthony Keech

2021-01-01

BACKGROUND: Men who are overweight or obese frequently have low serum testosterone concentrations, which are associated with incre..

Scholarly works icon

Telephone call reminders did not increase screening uptake more than SMS reminders: a recruitment study within a trial

Karen Bracken, Anthony Keech, Wendy Hague, Adrienne Kirby, Kristy P Robledo, Carolyn Allan, Ann Conway, Mark Daniel, Val Gebski, Mathis Grossmann, David J Handelsman, Warrick Inder, Alicia Jenkins, Robert McLachlan, Bronwyn Stuckey, Bu B Yeap, Gary Wittert

2019-08-01

OBJECTIVES: The aim of the study was to compare the response rates and costs of phone call vs. short message service (SMS) screeni..

Scholarly works icon

Testosterone therapy to prevent type 2 diabetes mellitus in at-risk men (T4DM): Design and implementation of a double-blind randomized controlled trial

Gary Wittert, Evan Atlantis, Carolyn Allan, Karen Bracken, Ann Conway, Mark Daniel, Val Gebski, Mathis Grossmann, Wendy Hague, David J Handelsman, Warrick Inder, Alicia Jenkins, Anthony Keech, Robert McLachlan, Kristy Robledo, Bronwyn Stuckey, Bu B Yeap

2019-04-01

BACKGROUND: Low circulating testosterone is associated with an increased risk of developing type 2 diabetes (T2DM) in overweight m..

Scholarly works icon

Testosterone treatment in older men: clinical implications and unresolved questions from the Testosterone Trials

Bu B Yeap, Stephanie T Page, Mathis Grossmann

2018-08-01

A decrease in the concentration of circulating testosterone in many older men is a biomarker and possibly a rectifiable contributi..

University of Melbourne Researchers