Long Lived, Virus Resistant Immune Cells

Grant number: 1045205 | Funding period: 2013 - 2016

Completed

Abstract

Vaccines that deposit memory T cells within the lung, gut and genital tract hold enormous therapeutic potential, as these mucosal surfaces are major portals of entry into the body for many viruses. However, the accumulation of large numbers of T cells within the mucosal tissue may increase the number of target cells for T cell trophic viruses (eg HIV) to infect. We will explore factors that are important in the generation of mucosal memory T cells that are also resistant to virus infection.

Related publications (4)

Nasal-associated lymphoid tissues (NALTs) support the recall but not priming of influenza virus-specific cytotoxic T cells

A Pizzolla, Z Wang, JR Groom, K Kedzierska, AG Brooks, PC Reading, LM Wakim

2017-05-16

The lymphoid tissue that drains the upper respiratory tract represents an important induction site for cytotoxic T lymphocyte (CTL..

Endogenous murine BST-2/tetherin is not a major restriction factor of influenza a virus infection

SL Londrigan, MD Tate, ER Job, JM Moffat, LM Wakim, CA Gonelli, DFJ Purcell, AG Brooks, JA Villadangos, PC Reading, JD Mintern

2015-11-01

BST-2 (tetherin, CD317, HM1.24) restricts virus growth by tethering enveloped viruses to the cell surface. The role of BST-2 durin..

Respiratory DC use IFITM3 to avoid direct viral infection and safeguard virus-specific CD8 T cell priming

G Infusini, JM Smith, H Yuan, A Pizzolla, WC Ng, SL Londrigan, A Haque, PC Reading, JA Villadangos, LM Wakim

2015-11-01

Respiratory dendritic cells (DC) play a pivotal role in the initiation of adaptive immune responses to influenza virus. To do this..

Antibody-targeted vaccination to lung dendritic cells generates tissue-resident memory CD8 T cells that are highly protective against influenza virus infection

LM Wakim, J Smith, I Caminschi, MH Lahoud, JA Villadangos

2015-09-19

Influenza virus gains entry into the body by inhalation and initiates its replication cycle within the lung. The early stage of in..

University of Melbourne Researchers

Linda Wakim