UTILIZATION OF GENE-ENGINEERED T CELLS FOR ENHANCING CANCER IMMUNOTHERAPY

Grant number: 1041828 | Funding period: 2013 - 2017

Completed

Abstract

Killer T lymphocytes can penetrate tumours and their transfer into cancer patients has demonstrated some encouraging results, but this form of therapy and other approaches including vaccination remain ineffective in most cancer patients. In this project, we propose to improve the tumour trafficking and anti-tumour activities of killer cells by genetically engineering them with proteins that will enable them to recognise and destroy cancer cells, whilst minimizing toxicity to normal tissue.

Related publications (19)

Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity

Junyun Lai, Sherly Mardiana, Imran G House, Kevin Sek, Melissa A Henderson, Lauren Giuffrida, Amanda XY Chen, Kirsten L Todd, Emma Petley, Jack D Chan, Emma M Carrington, Andrew M Lew, Benjamin J Solomon, Joseph A Trapani, Katherine Kedzierska, Maximilien Evrard, Stephin J Vervoort, Jason Waithman, Phillip K Darcy, Paul A Beavis

2020-05-18

Adoptive cell therapies using genetically engineered T cell receptor or chimeric antigen receptor T cells are emerging forms of im..

Targeting Adenosine Receptor Signaling in Cancer Immunotherapy

Kevin Sek, Christina Molck, Gregory D Stewart, Lev Kats, Phillip K Darcy, Paul A Beavis

2018-12-01

Dual PD-1 and CTLA-4 Checkpoint Blockade Promotes Antitumor Immune Responses through CD4( )Foxp3(-) Cell-Mediated Modulation of CD103( ) Dendritic Cells

Paul A Beavis, Melissa A Henderson, Lauren Giuffrida, Alexander J Davenport, Emma V Petley, Imran G House, Junyun Lai, Kevin Sek, Nicole Milenkovski, Liza B John, Sherly Mardiana, Clare Y Slaney, Joseph A Trapani, Sherene Loi, Michael H Kershaw, Nicole M Haynes, Phillip K Darcy

2018-09-01

Enumeration, functional responses and cytotoxic capacity of MAIT cells in newly diagnosed and relapsed multiple myeloma

Nicholas A Gherardin, Liyen Loh, Lorenztino Admojo, Alexander J Davenport, Kelden Richardson, Amy Rogers, Phillip K Darcy, Misty R Jenkins, H Miles Prince, Simon J Harrison, Hang Quach, David P Fairlie, Katherine Kedzierska, James McCluskey, Adam P Uldrich, Paul J Neeson, David S Ritchie, Dale I Godfrey

2018-03-07

Combined CDK4/6 and PI3K alpha Inhibition Is Synergistic and Immunogenic in Triple-Negative Breast Cancer

Zhi Ling Teo, Stephanie Versaci, Sathana Dushyanthen, Franco Caramia, Peter Savas, Chris P Mintoff, Magnus Zethoven, Balaji Virassamy, Stephen J Luen, Grant A McArthur, Wayne A Phillips, Phillip K Darcy, Sherene Loi

2017-11-15

Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer

Sathana Dushyanthen, Zhi Ling Teo, Franco Caramia, Peter Savas, Christopher P Mintoff, Balaji Virassamy, Melissa A Henderson, Stephen J Luen, Mariam Mansour, Michael H Kershaw, Joseph A Trapani, Paul J Neeson, Roberto Salgado, Grant A McArthur, Justin M Balko, Paul A Beavis, Phillip K Darcy, Sherene Loi

2017-09-19

A Novel Target Antigen for the Treatment of Acute Myeloid Leukemia by CAR T Cells

Paul A Beavis, Kevin Sek, Phillip K Darcy

2017-09-06

A novel combination strategy for effectively targeting cancer stem-like cells

Paul A Beavis, Emma V Petley, Phillip K Darcy

2017-08-01

Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer

Emma Nolan, Peter Savas, Antonia N Policheni, Phillip K Darcy, Francois Vaillant, Christopher P Mintoff, Sathana Dushyanthen, Mariam Mansour, Jia-Min B Pang, Stephen B Fox, Charles M Perou, Jane E Visvader, Daniel HD Gray, Sherene Loi, Geoffrey J Lindeman

2017-06-07

A Multifunctional Role for Adjuvant Anti-4-1BB Therapy in Augmenting Antitumor Response by Chimeric Antigen Receptor T Cells

Sherly Mardiana, Liza B John, Melissa A Henderson, Clare Y Slaney, Bianca von Scheidt, Lauren Giuffrida, Alexander J Davenport, Joseph A Trapani, Paul J Neeson, Sherene Loi, Nicole M Haynes, Michael H Kershaw, Paul A Beavis, Phillip K Darcy

2017-03-15

Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy

Paul A Beavis, Melissa A Henderson, Lauren Giuffrida, Jane K Mills, Kevin Sek, Ryan S Cross, Alexander J Davenport, Liza B John, Sherly Mardiana, Clare Y Slaney, Ricky W Johnstone, Joseph A Trapani, John Stagg, Sherene Loi, Lev Kats, David Gyorki, Michael H Kershaw, Phillip K Darcy

2017-03-01

Reprogramming the tumor microenvironment to enhance adoptive cellular therapy

Paul A Beavis, Clare Y Slaney, Michael H Kershaw, David Gyorki, Paul J Neeson, Phillip K Darcy

2016-02-01

Cancer immunotherapy utilizing gene-modified T cells: From the bench to the clinic

Connie PM Duong, Carmen SM Yong, Michael H Kershaw, Clare Y Slaney, Phillip K Darcy

2015-10-01

Relevance of tumor-infiltrating lymphocytes in breast cancer

Sathana Dushyanthen, Paul A Beavis, Peter Savas, Zhi Ling Teo, Chenhao Zhou, Mariam Mansour, Phillip K Darcy, Sherene Loi

2015-08-24

Adenosine Receptor 2A Blockade Increases the Efficacy of Anti-PD-1 through Enhanced Antitumor T-cell Responses

Paul A Beavis, Nicole Milenkovski, Melissa A Henderson, Liza B John, Bertrand Allard, Sherene Loi, Michael H Kershaw, John Stagg, Phillip K Darcy

2015-05-01

CAR-T Cells Inflict Sequential Killing of Multiple Tumor Target Cells

Alexander J Davenport, Misty R Jenkins, Ryan S Cross, Carmen S Yong, H Miles Prince, David S Ritchie, Joseph A Trapani, Michael H Kershaw, Phillip K Darcy, Paul J Neeson

2015-05-01

Adoptive immunotherapy: a new era for the treatment of cancer

Phillip K Darcy, Paul J Neeson

2015-01-01

Enhancing the efficacy of adoptive cellular therapy by targeting tumor-induced immunosuppression

Paul A Beavis, Clare Y Slaney, Michael H Kershaw, Paul J Neeson, Phillip K Darcy

2015-01-01

Trafficking of T Cells into Tumors

Clare Y Slaney, Michael H Kershaw, Phillip K Darcy

2014-12-15

Researchers

Phillip Darcy