MOLECULAR IMAGING OF NEURODEGENERATION

Grant number: 1046471 | Funding period: 2013 - 2018

Completed

Abstract

This research proposal outlines studies aimed at identifying specific biomarkers of neurodegeneration. Given the complexity and clinical overlap of these disorders the identification of diagnostic biomarkers for their early detection is crucial; especially in the identification of at-risk individuals before the development of symptoms. This will allow early intervention with disease-modifying medications which by arresting neuronal loss would prevent or delay onset of the disease.

Related publications (8)

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Aβ Imaging in Aging, Alzheimer’s Disease, and Other Neurodegenerative Conditions

Victor L Villemagne, Vincent Doré, Samantha Burnham, Christopher C Rowe

2021-01-01

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Multisite study of the relationships between antemortem [C-11]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology

Renaud La Joie, Nagehan Ayakta, William W Seeley, Ewa Borys, Adam L Boxer, Charles Decarli, Vincent Dore, Lea T Grinberg, Eric Huang, Ji-Hye Hwang, Milos D Ikonomovic, Clifford Jack, William J Jagusth, Lee-Way Jin, William E Klunk, Julia Kofler, Orit H Lesman-Segev, Samuel N Lockhart, Val J Lowe, Colin L Masters

2019-02-01

INTRODUCTION: We sought to establish the relationships between standard postmortem measures of AD neuropathology and antemortem [1..

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Assessment of amyloid β in pathologically confirmed frontotemporal dementia syndromes.

Rachel H Tan, Jillian J Kril, Yue Yang, Nicole Tom, John R Hodges, Victor L Villemagne, Christopher C Rowe, Cristian E Leyton, John BJ Kwok, Lars M Ittner, Glenda M Halliday

2017-01-01

INTRODUCTION: The diagnostic utility of in vivo amyloid β (Aβ) imaging to aid in the clinical distinction between frontotemporal d..

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Tau imaging in the study of ageing, Alzheimer's disease, and other neurodegenerative conditions

Victor L Villemagne, Nobuyuki Okamura

2016-02-01

In vivo tau imaging allows a deeper understanding of tau deposition in the brain, providing insights into the causes, diagnosis an..

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Untangling tau imaging.

Victor L Villemagne, Nobuyuki Okamura, Christopher C Rowe

2016-01-01

In vivo imaging of tau deposits is providing a better understanding of the temporal and spatial tau deposition in the brain, allow..

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Tau imaging: early progress and future directions

Victor L Villemagne, Michelle T Fodero-Tavoletti, Colin L Masters, Christopher C Rowe

2015-01-01

Use of selective in-vivo tau imaging will enable improved understanding of tau aggregation in the brain, facilitating research int..

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In vivo tau imaging: Obstacles and progress

Victor L Villemagne, Nobuyuki Okamura

2014-06-01

The military conflicts of the last decade have highlighted the growing problem of traumatic brain injury in combatants returning f..

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In vivo evaluation of a novel tau imaging tracer for Alzheimer's disease

Victor L Villemagne, Shozo Furumoto, Michelle T Fodero-Tavoletti, Rachel S Mulligan, John Hodges, Ryuichi Harada, Paul Yates, Olivier Piguet, Svetlana Pejoska, Vincent Dore, Kazuhiko Yanai, Colin L Masters, Yukitsuka Kudo, Christopher C Rowe, Nobuyuki Okamura

2014-05-01

PURPOSE: Diagnosis of tauopathies such as Alzheimer's disease (AD) still relies on post-mortem examination of the human brain. A n..

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