MOLECULAR IMAGING OF NEURODEGENERATION
Grant number: 1046471 | Funding period: 2013 - 2018
This research proposal outlines studies aimed at identifying specific biomarkers of neurodegeneration. Given the complexity and clinical overlap of these disorders the identification of diagnostic biomarkers for their early detection is crucial; especially in the identification of at-risk individuals before the development of symptoms. This will allow early intervention with disease-modifying medications which by arresting neuronal loss would prevent or delay onset of the disease.
Related publications (8)
Multisite study of the relationships between antemortem [C-11]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology
Renaud La Joie, Nagehan Ayakta, William W Seeley, Ewa Borys, Adam L Boxer, Charles Decarli, Vincent Dore, Lea T Grinberg, Eric Huang, Ji-Hye Hwang, Milos D Ikonomovic, Clifford Jack, William J Jagusth, Lee-Way Jin, William E Klunk, Julia Kofler, Orit H Lesman-Segev, Samuel N Lockhart, Val J Lowe, Colin L Masters
INTRODUCTION: We sought to establish the relationships between standard postmortem measures of AD neuropathology and antemortem [1..
Assessment of amyloid β in pathologically confirmed frontotemporal dementia syndromes.
Rachel H Tan, Jillian J Kril, Yue Yang, Nicole Tom, John R Hodges, Victor L Villemagne, Christopher C Rowe, Cristian E Leyton, John BJ Kwok, Lars M Ittner, Glenda M Halliday
INTRODUCTION: The diagnostic utility of in vivo amyloid β (Aβ) imaging to aid in the clinical distinction between frontotemporal d..
In vivo evaluation of a novel tau imaging tracer for Alzheimer's disease
Victor L Villemagne, Shozo Furumoto, Michelle T Fodero-Tavoletti, Rachel S Mulligan, John Hodges, Ryuichi Harada, Paul Yates, Olivier Piguet, Svetlana Pejoska, Vincent Dore, Kazuhiko Yanai, Colin L Masters, Yukitsuka Kudo, Christopher C Rowe, Nobuyuki Okamura
PURPOSE: Diagnosis of tauopathies such as Alzheimer's disease (AD) still relies on post-mortem examination of the human brain. A n..