DELINEATING THE CONTRIBUTION OF INFLAMMATION TO LONG-TERM NEURODEGENERATION, NEUROPSYCHIATRIC OUTCOMES AND SEIZURE SUSCEPTIBILITY FOLLOWING TRAUMATIC INJURY TO THE IMMATURE BRAIN
Grant number: 1052505 | Funding period: 2013 - 2017
Epilepsy is a common, debilitating consequence of brain injury in children, however little is known about factors which trigger its development. This proposal investigates the contribution of the acute inflammatory response to long-term neuronal loss, functional outcomes and seizure activity after paediatric brain injury. Understanding how epilepsy and brain damage progresses after injury will aid the development of drugs to improve long-term outcomes in brain-injured children.
Related publications (2)
Early Gelatinase Activity Is Not a Determinant of Long-Term Recovery after Traumatic Brain Injury in the Immature Mouse
Bridgette D Semple, Linda J Noble-Haeusslein, Major Gooyit, Kayleen G Tercovich, Zhihong Peng, Trung T Nguyen, Valerie A Schroeder, Mark A Suckow, Mayland Chang, Jacob Raber, Alpa Trivedi
Sociosexual and Communication Deficits after Traumatic Injury to the Developing Murine Brain
Bridgette D Semple, Linda J Noble-Haeusslein, Yong Jun Kwon, Pingdewinde N Sam, A Matt Gibson, Sarah Grissom, Sienna Brown, Zahra Adahman, Christopher A Hollingsworth, Alexander Kwakye, Kayleen Gimlin, Elisabeth A Wilde, Gerri Hanten, Harvey S Levin, A Katrin Schenk