DELINEATING THE CONTRIBUTION OF INFLAMMATION TO LONG-TERM NEURODEGENERATION, NEUROPSYCHIATRIC OUTCOMES AND SEIZURE SUSCEPTIBILITY FOLLOWING TRAUMATIC INJURY TO THE IMMATURE BRAIN

Grant number: 1052505 | Funding period: 2013 - 2017

Completed

Abstract

Epilepsy is a common, debilitating consequence of brain injury in children, however little is known about factors which trigger its development. This proposal investigates the contribution of the acute inflammatory response to long-term neuronal loss, functional outcomes and seizure activity after paediatric brain injury. Understanding how epilepsy and brain damage progresses after injury will aid the development of drugs to improve long-term outcomes in brain-injured children.