DELINEATING THE CONTRIBUTION OF INFLAMMATION TO LONG-TERM NEURODEGENERATION, NEUROPSYCHIATRIC OUTCOMES AND SEIZURE SUSCEPTIBILITY FOLLOWING TRAUMATIC INJURY TO THE IMMATURE BRAIN
Grant number: 1052505 | Funding period: 2013 - 2017
Epilepsy is a common, debilitating consequence of brain injury in children, however little is known about factors which trigger its development. This proposal investigates the contribution of the acute inflammatory response to long-term neuronal loss, functional outcomes and seizure activity after paediatric brain injury. Understanding how epilepsy and brain damage progresses after injury will aid the development of drugs to improve long-term outcomes in brain-injured children.
Related publications (7)
Sex-dependent changes in neuronal morphology and psychosocial behaviors after pediatric brain injury
Bridgette D Semple, Shilpi Dixit, Sandy R Shultz, Wah Chin Boon, Terence J O'Brien
Chronic social behavior problems after pediatric traumatic brain injury (TBI) significantly contribute to poor quality of life for..
Early Gelatinase Activity Is Not a Determinant of Long-Term Recovery after Traumatic Brain Injury in the Immature Mouse
Bridgette D Semple, Linda J Noble-Haeusslein, Major Gooyit, Kayleen G Tercovich, Zhihong Peng, Trung T Nguyen, Valerie A Schroeder, Mark A Suckow, Mayland Chang, Jacob Raber, Alpa Trivedi
The gelatinases, matrix metalloproteinases (MMP)-2 and MMP-9, are thought to be key mediators of secondary damage in adult animal ..
Found in translation: Understanding the biology and behavior of experimental traumatic brain injury.
Corina O Bondi, Bridgette D Semple, Linda J Noble-Haeusslein, Nicole D Osier, Shaun W Carlson, C Edward Dixon, Christopher C Giza, Anthony E Kline
The aim of this review is to discuss in greater detail the topics covered in the recent symposium entitled "Traumatic brain injury..
Sociosexual and Communication Deficits after Traumatic Injury to the Developing Murine Brain
Bridgette D Semple, Linda J Noble-Haeusslein, Yong Jun Kwon, Pingdewinde N Sam, A Matt Gibson, Sarah Grissom, Sienna Brown, Zahra Adahman, Christopher A Hollingsworth, Alexander Kwakye, Kayleen Gimlin, Elisabeth A Wilde, Gerri Hanten, Harvey S Levin, A Katrin Schenk
Despite the life-long implications of social and communication dysfunction after pediatric traumatic brain injury, there is a poor..