Iron accumulation in C.elegans: a model of ageing
Grant number: DP130100357 | Funding period: 2013 - 2016
This project will investigate the role of biological metals in the process of ageing, the causes of which remain unresolved. The practical outcomes for society are broad; beyond improving understandings of the basic biology of ageing, this study will provide new insight and approaches that can be used to optimise lifespan.
Related publications (5)
phi XANES: In vivo imaging of metal-protein coordination environments
Simon A James, Dominic J Hare, Nicole L Jenkins, Martin D de Jonge, Ashley I Bush, Gawain McColl
We have developed an X-ray absorption near edge structure spectroscopy method using fluorescence detection for visualizing in vivo..
High-resolution complementary chemical imaging of bio-elements in Caenorhabditis elegans
Dominic J Hare, Michael WM Jones, Verena C Wimmer, Nicole L Jenkins, Martin D de Jonge, Ashley I Bush, Gawain McColl
Here, we present a sub-μm multimodal approach to image essential elements in Caenorhabditis elegans. A combination of chemical ima..
Direct in vivo imaging of ferrous iron dyshomeostasis in ageing Caenorhabditis elegans
Simon A James, Blaine R Roberts, Dominic J Hare, Martin D de Jonge, Ian E Birchall, Nicole L Jenkins, Robert A Cherny, Ashley I Bush, Gawain McColl
Iron is essential for eukaryotic biochemistry. Systematic trafficking and storage is required to maintain supply of iron while pre..
Direct in vivo imaging of essential bioinorganics in Caenorhabditis elegans
Simon A James, Martin D de Jonge, Daryl L Howard, Ashley I Bush, David Paterson, Gawain McColl
Metals are essential in biochemistry, with highly regulated localisation and concentration. To continue elucidating the impact of ..