Wiring the gut's nervous system: formation and maturation of synapses
Grant number: DP130101596 | Funding period: 2013 - 2016
This project aims to determine how nerve circuits controlling intestinal functions develop; specifically how communication between specific nerve cells is established once they appear in the embryonic gut. It will fill a major hole in existing knowledge of mechanisms regulating the development of normal digestive behaviours.
Related publications (8)
alpha-Synuclein Regulates Development and Function of Cholinergic Enteric Neurons in the Mouse Colon
M Swaminathan, C Fung, D Finkelstein, JC Bornstein, JPP Foong
Alpha-Synuclein (α-Syn) is expressed in the central nervous system and the nervous system of the gut (enteric nervous system, ENS)..
Cholinergic Submucosal Neurons Display Increased Excitability Following in Vivo Cholera Toxin Exposure in Mouse Ileum
Candice Fung, Katerina Koussoulas, Petra Unterweger, Andrew M Allen, Joel C Bornstein, Jaime PP Foong
Cholera-induced hypersecretion causes dehydration and death if untreated. Cholera toxin (CT) partly acts via the enteric nervous s..
Neurally Released GABA Acts via GABA(C) Receptors to Modulate Ca2 Transients Evoked by Trains of Synaptic Inputs, but Not Responses Evoked by Single Stimuli, in Myenteric Neurons of Mouse Ileum
Katerina Koussoulas, Mathusi Swaminathan, Candice Fung, Joel C Bornstein, Jaime PP Foong
γ-Aminobutyric Acid (GABA) and its receptors, GABAA,B,C, are expressed in several locations along the gastrointestinal tract. Neve..
Optogenetic Demonstration of Functional Innervation of Mouse Colon by Neurons Derived From Transplanted Neural Cells
Lincon A Stamp, Rachel M Gwynne, Jaime PP Foong, Alan E Lomax, Marlene M Hao, David I Kaplan, Christopher A Reid, Steven Petrou, Andrew M Allen, Joel C Bornstein, Heather M Young
BACKGROUND & AIMS: Cell therapy offers the potential to treat gastrointestinal motility disorders caused by diseased or absent ent..
Differences in CART expression and cell cycle behavior discriminate sympathetic neuroblast from chromaffin cell lineages in mouse sympathoadrenal cells
Wing Hei Chan, David G Gonsalvez, Heather M Young, E Michelle Southard-Smith, Kylie N Cane, Colin R Anderson
Adrenal medullary chromaffin cells and peripheral sympathetic neurons originate from a common sympathoadrenal (SA) progenitor cell..
Changes in Nicotinic Neurotransmission during Enteric Nervous System Development
Jaime Pei Pei Foong, Caroline S Hirst, Marlene M Hao, Sonja J McKeown, Werend Boesmans, Heather M Young, Joel C Bornstein, Pieter Vanden Berghe
Acetylcholine-activating pentameric nicotinic receptors (nAChRs) are an essential mode of neurotransmission in the enteric nervous..
Ion Channel Expression in the Developing Enteric Nervous System
Caroline S Hirst, Jaime PP Foong, Lincon A Stamp, Emily Fegan, Stephan Dent, Edward C Cooper, Alan E Lomax, Colin R Anderson, Joel C Bornstein, Heather M Young, Sonja J McKeown
The enteric nervous system arises from neural crest-derived cells (ENCCs) that migrate caudally along the embryonic gut. The expre..