Wiring the gut's nervous system: formation and maturation of synapses

Grant number: DP130101596 | Funding period: 2013 - 2016

Completed

Abstract

This project aims to determine how nerve circuits controlling intestinal functions develop; specifically how communication between specific nerve cells is established once they appear in the embryonic gut. It will fill a major hole in existing knowledge of mechanisms regulating the development of normal digestive behaviours.

Related publications (8)

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alpha-Synuclein Regulates Development and Function of Cholinergic Enteric Neurons in the Mouse Colon

M Swaminathan, C Fung, D Finkelstein, JC Bornstein, JPP Foong

2019-12-15

Alpha-Synuclein (α-Syn) is expressed in the central nervous system and the nervous system of the gut (enteric nervous system, ENS)..

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Cholinergic Submucosal Neurons Display Increased Excitability Following in Vivo Cholera Toxin Exposure in Mouse Ileum

Candice Fung, Katerina Koussoulas, Petra Unterweger, Andrew M Allen, Joel C Bornstein, Jaime PP Foong

2018-03-21

Cholera-induced hypersecretion causes dehydration and death if untreated. Cholera toxin (CT) partly acts via the enteric nervous s..

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Neurally Released GABA Acts via GABA(C) Receptors to Modulate Ca2 Transients Evoked by Trains of Synaptic Inputs, but Not Responses Evoked by Single Stimuli, in Myenteric Neurons of Mouse Ileum

Katerina Koussoulas, Mathusi Swaminathan, Candice Fung, Joel C Bornstein, Jaime PP Foong

2018-02-13

γ-Aminobutyric Acid (GABA) and its receptors, GABAA,B,C, are expressed in several locations along the gastrointestinal tract. Neve..

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Optogenetic Demonstration of Functional Innervation of Mouse Colon by Neurons Derived From Transplanted Neural Cells

Lincon A Stamp, Rachel M Gwynne, Jaime PP Foong, Alan E Lomax, Marlene M Hao, David I Kaplan, Christopher A Reid, Steven Petrou, Andrew M Allen, Joel C Bornstein, Heather M Young

2017-05-01

BACKGROUND & AIMS: Cell therapy offers the potential to treat gastrointestinal motility disorders caused by diseased or absent ent..

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Differences in CART expression and cell cycle behavior discriminate sympathetic neuroblast from chromaffin cell lineages in mouse sympathoadrenal cells

Wing Hei Chan, David G Gonsalvez, Heather M Young, E Michelle Southard-Smith, Kylie N Cane, Colin R Anderson

2016-02-01

Adrenal medullary chromaffin cells and peripheral sympathetic neurons originate from a common sympathoadrenal (SA) progenitor cell..

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ENS Development Research Since 1983: Great Strides but Many Remaining Challenges

Heather M Young, Lincon A Stamp, Sonja J McKeown

2016-01-01

The first enteric nervous system (ENS) conference, organized by Marcello Costa and John Furness, was held in Adelaide, Australia i..

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Changes in Nicotinic Neurotransmission during Enteric Nervous System Development

Jaime Pei Pei Foong, Caroline S Hirst, Marlene M Hao, Sonja J McKeown, Werend Boesmans, Heather M Young, Joel C Bornstein, Pieter Vanden Berghe

2015-05-06

Acetylcholine-activating pentameric nicotinic receptors (nAChRs) are an essential mode of neurotransmission in the enteric nervous..

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Ion Channel Expression in the Developing Enteric Nervous System

Caroline S Hirst, Jaime PP Foong, Lincon A Stamp, Emily Fegan, Stephan Dent, Edward C Cooper, Alan E Lomax, Colin R Anderson, Joel C Bornstein, Heather M Young, Sonja J McKeown

2015-03-23

The enteric nervous system arises from neural crest-derived cells (ENCCs) that migrate caudally along the embryonic gut. The expre..

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