MOLECULAR SUBTYPESOF HIGH GRADE SEROUS OVARIAN CANCER - LEVERAGING OF TCGA, OCAC, OTTA, AND AOCS GENOME AND GENOMIC DATASETS
Grant number: W81XWH-12-1-0104 | Funding period: 2012 - 2014
PUBLIC ABSTRACT More and more, researchers are learning that ovarian cancer is not one disease but, rather, a number of distinct diseases with different genetic, and likely different environmental, risk factors. However, we still treat ovarian cancer as if it were a single disease, and, sadly, many women simply do not respond to current treatment options. Treatment improvements rely on understanding how tumors differ from each other and targeting treatment accordingly. This proposal explores a newly recognized and important aspect of tumor difference in women with high-grade serous cancer, the most common and deadly form of ovarian cancer. Ovarian tumors are diagnosed by pathologists based o..View full description
Related publications (2)
Association of p16 expression with prognosis varies across ovarian carcinoma histotypes: an Ovarian Tumor Tissue Analysis consortium study
Peter F Rambau, Robert A Vierkant, Maria P Intermaggio, Linda E Kelemen, Marc T Goodman, Esther Herpel, Paul D Pharoah, Stefan Kommoss, Mercedes Jimenez-Linan, Beth Y Karlan, Aleksandra Gentry-Maharaj, Usha Menon, Susanna Hernando Polo, Francisco J Candido dos Reis, Jennifer Anne Doherty, Simon A Gayther, Raghwa Sharma, Melissa C Larson, Paul R Harnett, Emma Hatfield
We aimed to validate the prognostic association of p16 expression in ovarian high-grade serous carcinomas (HGSC) and to explore it..
Efficient molecular subtype classification of high-grade serous ovarian cancer
Huei San Leong, Laura Galletta, Dariush Etemadmoghadam, Joshy George, Martin Koebel, Susan J Ramus, David Bowtell
High-grade serous carcinomas (HGSCs) account for approximately 70% of all epithelial ovarian cancers diagnosed. Using microarray g..