Functional tracing of brain circuitry by a novel approach
Grant number: DP130104661 | Funding period: 2013 - 2016
A genetically modified virus is taken up by axon terminals (the 'output' part of a nerve cell) and transported by the cell back to the cell body (its 'input' part). Once there, it makes a protein that makes the cell sensitive to blue light. This new tool may be instrumental in answering questions about nerve connections that cannot be answered in other ways.
Related publications (3)
On the presence and functional significance of sympathetic premotor neurons with collateralized spinal axons in the rat
David GS Farmer, Natasha Pracejus, Bowen Dempsey, Anita Turner, Phillip Bokiniec, Julian FR Paton, Anthony E Pickering, Jasmine Burguet, Philippe Andrey, Ann K Goodchild, Robin M McAllen, Simon McMullan
KEY POINTS: Spinally-projecting neurons of the rostral ventrolateral medulla (RVLM) determine sympathetic outflow to different ter..
Brainstem sources of cardiac vagal tone and respiratory sinus arrhythmia
David GS Farmer, Mathias Dutschmann, Julian FR Paton, Anthony E Pickering, Robin M McAllen
KEY POINTS: Cardiac vagal tone is a strong predictor of health, although its central origins are unknown. Respiratory-linked fluct..