Alphaherpesvirus Recombination - Safety Implications for Attenuated Herpesvirus Vaccines
Grant number: DP130103991 | Funding period: 2013 - 2016
Under certain conditions some herpesviruses, including mild vaccine strains, can recombine to generate virulent viruses. Following findings that this occurred naturally between Australian poultry vaccines, with devastating results, this project will study natural herpesvirus recombination with the aim of allowing vaccines to be used more safely.
Related publications (5)
Low genetic diversity among historical and contemporary clinical isolates of felid herpesvirus 1
Paola K Vaz, Natalie Job, Jacquelyn Horsington, Nino Ficorilli, Michael J Studdert, Carol A Hartley, James R Gilkerson, Glenn F Browning, Joanne M Devlin
BACKGROUND: Felid herpesvirus 1 (FHV-1) causes upper respiratory tract diseases in cats worldwide, including nasal and ocular disc..
Spread of the newly emerging infectious laryngotracheitis viruses in Australia
Rebecca Agnew-Crumpton, Paola K Vaz, Joanne M Devlin, Denise O'Rourke, Hayley Patricia Blacker-Smith, Barbara Konsak-Ilievski, Carol A Hartley, Amir H Noormohammadi
Infectious laryngotracheitis (ILT) is a significant viral disease of chickens in many countries around the globe. In this report t..
Evidence of widespread natural recombination among field isolates of equine herpesvirus 4 but not among field isolates of equine herpesvirus 1
PK Vaz, J Horsington, CA Hartley, GF Browning, NP Ficorilli, MJ Studdert, JR Gilkerson, JM Devlin
Recombination in alphaherpesviruses allows evolution to occur in viruses that have an otherwise stable DNA genome with a low rate ..
Protection Induced in Broiler Chickens following Drinking-Water Delivery of Live Infectious Laryngotracheitis Vaccines against Subsequent Challenge with Recombinant Field Virus
Mesula G Korsa, Glenn F Browning, Mauricio JC Coppo, Alistair R Legione, James R Gilkerson, Amir H Noormohammadi, Paola K Vaz, Sang-Won Lee, Joanne M Devlin, Carol A Hartley
Infectious laryngotracheitis virus (ILTV) causes acute upper respiratory tract disease in chickens. Attenuated live ILTV vaccines ..
Growth Kinetics and Transmission Potential of Existing and Emerging Field Strains of Infectious Laryngotracheitis Virus
Sang-Won Lee, Carol A Hartley, Mauricio JC Coppo, Paola K Vaz, Alistair R Legione, Jose A Quinteros, Amir H Noormohammadi, Phillip F Markham, Glenn F Browning, Joanne M Devlin
Attenuated live infectious laryngotracheitis virus (ILTV) vaccines are widely used in the poultry industry to control outbreaks of..