Development of next-generation nanoengineered advanced materials for targeted applications

Influence of Ionic Strength on the Deposition of Metal-Phenolic Networks

Junling Guo, Joseph J Richardson, Quinn A Besford, Andrew J Christofferson, Yunlu Dai, Chien W Ong, Blaise L Tardy, Kang Liang, Gwan H Choi, Jiwei Cui, Pil J Yoo, Irene Yarovsky, Frank Caruso

2017-10-10

Metal-phenolic networks (MPNs) are a versatile class of self-assembled materials that are able to form functional thin films on va..

Self-Assembled Nanoparticles from Phenolic Derivatives for Cancer Therapy

Yunlu Dai, Junling Guo, Ting-Yi Wang, Yi Ju, Andrew J Mitchell, Thomas Bonnard, Jiwei Cui, Joseph J Richardson, Christoph E Hagemeyer, Karen Alt, Frank Caruso

2017-08-23

Therapeutic nanoparticles hold clinical promise for cancer treatment by avoiding limitations of conventional pharmaceuticals. Here..

Tuning the Properties of Polymer Capsules for Cellular Interactions

Huanli Sun, Jiwei Cui, Yi Ju, Xi Chen, Edgar HH Wong, Jenny Tran, Greg G Qiao, Frank Caruso

2017-07-01

Particle-cell interactions are governed by, among other factors, the composition and surface properties of the particles. Herein, ..

Modular assembly of superstructures from polyphenol-functionalized building blocks

Junling Guo, Blaise L Tardy, Andrew J Christofferson, Yunlu Dai, Joseph J Richardson, Wei Zhu, Ming Hu, Yi Ju, Jiwei Cui, Raymond R Dagastine, Irene Yarovsky, Frank Caruso

2016-12-01

The organized assembly of particles into superstructures is typically governed by specific molecular interactions or external dire..

Thermally Induced Charge Reversal of Layer-by-Layer Assembled Single-Component Polymer Films

Joseph J Richardson, Blaise L Tardy, Hirotaka Ejima, Junling Guo, Jiwei Cui, Kang Liang, Gwan H Choi, Pil J Yoo, Bruno G De Geest, Frank Caruso

2016-03-23

Temperature can be harnessed to engineer unique properties for materials useful in various contexts and has been shown to affect t..

Photocontrolled Cargo Release from Dual Cross-Linked Polymer Particles

Shereen Tan, Jiwei Cui, Qiang Fu, Eunhyung Nam, Katharina Ladewig, Jing M Ren, Edgar HH Wong, Frank Caruso, Anton Blencowe, Greg G Qiao

2016-03-09

Burst release of a payload from polymeric particles upon photoirradiation was engineered by altering the cross-linking density. Th..

Structure Governs the Deformability of Polymer Particles in a Microfluidic Blood Capillary Model

Huanli Sun, Mattias Bjoernmalm, Jiwei Cui, Edgar HH Wong, Yunlu Dai, Qiong Dai, Greg G Qiao, Frank Caruso

2015-11-01

Particle stiffness is a design parameter that affects bionano interactions, including biodistribution kinetics and cellular proces..

Nanoporous Metal–Phenolic Particles as Ultrasound Imaging Probes for Hydrogen Peroxide

J Guo, X Wang, DC Henstridge, JJ Richardson, J Cui, A Sharma, MA Febbraio, K Peter, JB de Haan, CE Hagemeyer, F Caruso

2015-10-01

Nanoporous metal-phenolic particles are fabricated through the nanostructural replication of dense FeIII -TA complexes in nanoporo..

Boronate-Phenolic Network Capsules with Dual Response to Acidic pH and cis-Diols

Junling Guo, Huanli Sun, Karen Alt, Blaise L Tardy, Joseph J Richardson, Tomoya Suma, Hirotaka Ejima, Jiwei Cui, Christoph E Hagemeyer, Frank Caruso

2015-08-26

Dual-responsive boronate-phenolic network (BPN) capsules are fabricated by the complexation of phenylborate and phenolic materials..

Engineering Poly(ethylene glycol) Particles for Improved Biodistribution

Jiwei Cui, Robert De Rose, Karen Alt, Sheilajen Alcantara, Brett M Paterson, Kang Liang, Ming Hu, Joseph J Richardson, Yan Yan, Charmaine M Jeffery, Roger I Price, Karlheinz Peter, Christoph E Hagemeyer, Paul S Donnelly, Stephen J Kent, Frank Caruso

2015-02-01

We report the engineering of poly(ethylene glycol) (PEG) hydrogel particles using a mesoporous silica (MS) templating method via t..

Fabrication of ultra-thin polyrotaxane-based films via solid-state continuous assembly of polymers

Shereen Tan, Eunhyung Nam, Jiwei Cui, Chenglong Xu, Qiang Fu, Jing M Ren, Edgar HH Wong, Katharina Ladewig, Frank Caruso, Anton Blencowe, Greg G Qiao

2015-01-01

Surface-confined ultra-thin polyrotaxane (PRX)-based films with tunable composition, surface topology and swelling characteristics..

The role of capsule stiffness on cellular processing

Huanli Sun, Edgar HH Wong, Yan Yan, Jiwei Cui, Qiong Dai, Junling Guo, Greg G Qiao, Frank Caruso

2015-01-01

Particle stiffness is emerging as an important parameter in determining the cell uptake dynamics of particles. Understanding the e..

Fabrication of Chiral Stationary Phases via Continuous Assembly of Polymers for Resolution of Enantiomers by Liquid Chromatography

Stefanie N Guntari, Eunhyung Nam, Nina N Pranata, Kenneth Chia, Edgar HH Wong, A Blencowe, Tor K Goh, Frank Caruso, Greg G Qiao

2014-11-01

Precise stereochemical determination of chiral molecules is highly important, especially in the pharmaceutical industry where one ..

Endocytic Capsule Sensors for Probing Cellular Internalization

Kang Liang, Sylvia T Gunawan, Joseph J Richardson, Georgina K Such, Jiwei Cui, Frank Caruso

2014-10-01

A new class of polymer capsules with an in-built endocytic pH-coupled fluorescence switch is reported. These capsules display reve..

Continuous assembly of polymers via solid phase reactions

Eunhyung Nam, Jinguk Kim, Stefanie N Guntari, Helga Seyler, Qiang Fu, Edgar HH Wong, Anton Blencowe, David J Jones, Frank Caruso, Greg G Qiao

2014-09-01

The continuous assembly of polymers in the solid state via ring-opening metathesis polymerization (ssCAPROMP) is reported as an ef..

Emerging methods for the fabrication of polymer capsules

Jiwei Cui, Martin P van Koeverden, Markus Muellner, Kristian Kempe, Frank Caruso

2014-05-01

Hollow polymer capsules are attracting increasing research interest due to their potential application as drug delivery vectors, s..

Nanoscale engineering of low-fouling surfaces through polydopamine immobilisation of zwitterionic peptides

Jiwei Cui, Yi Ju, Kang Liang, Hirotaka Ejima, Samuel Loercher, Katelyn T Gause, Joseph J Richardson, Frank Caruso

2014-01-01

We report a versatile approach for the design of substrate-independent low-fouling surfaces via mussel-inspired immobilisation of ..

(Super)hydrophobic and Multilayered Amphiphilic Films Prepared by Continuous Assembly of Polymers

Stefanie N Guntari, Aaron CH Khin, Edgar HH Wong, Tor K Goh, Anton Blencowe, Frank Caruso, Greg G Qiao

2013-11-06

The continuous assembly of polymers (CAP) is used to fabricate tailored nanocoatings on a wide variety of substrates. Ring-opening..

Assembly of Nanostructured Films with Hydrophobic Subcompartments via Continuous Assembly of Polymers

Edgar HH Wong, Martin P van Koeverden, Eunhyung Nam, Stefanie N Guntari, Steven Harris Wibowo, Anton Blencowe, Frank Caruso, Greg G Qiao

2013-10-08

The generation of nanoscale polymer films using complex, hierarchically structured (bio)macromolecular architectures has important..

Assembly of Free-Standing Polypeptide Films via the Synergistic Combination of Hyperbranched Macroinitiators, the Grafting-From Approach, and Cross-Chain Termination

Steven Harris Wibowo, Edgar HH Wong, Adrian Sulistio, Stefanie N Guntari, Anton Blencowe, Frank Caruso, Greg G Qiao

2013-09-06

Cross-linked polypeptide-based films are fabricated via a novel and robust method employing surface-initiated ring opening polymer..

Mechanics of pH-Responsive Hydrogel Capsules

James P Best, Martin P Neubauer, Sameen Javed, Henk H Dam, Andreas Fery, Frank Caruso

2013-08-06

While soft hydrogel nano- and microstructures hold great potential for therapeutic treatments and in vivo applications, their nano..

Tuning the Mechanical Properties of Nanoporous Hydrogel Particles via Polymer Cross-Linking

James P Best, Jiwei Cui, Markus Muellner, Frank Caruso

2013-08-06

Soft hydrogel particles with tunable mechanical properties are promising for next-generation therapeutic applications. This is due..

Low-Fouling, Biospecific Films Prepared by the Continuous Assembly of Polymers

Stefanie N Guntari, Edgar HH Wong, Tor K Goh, Rona Chandrawati, Anton Blencowe, Frank Caruso, Greg G Qiao

2013-08-01

We report that the continuous assembly of polymers (CAP) approach, mediated by ring-opening metathesis polymerization (ROMP), is a..

Mechanically Tunable, Self-Adjuvanting Nanoengineered Polypeptide Particles

Jiwei Cui, Robert De Rose, James P Best, Angus PR Johnston, Sheilajen Alcantara, Kang Liang, Georgina K Such, Stephen J Kent, Frank Caruso

2013-07-05

DNA-loaded polypeptide particles are prepared via templated assembly of mesoporous silica for the delivery of adjuvants. The elast..