Norovirus Replication and Pathogenesis

Grant number: 1010327 | Funding period: 2013 - 2013

Completed

Abstract

Viral infections of the gut are one of the most debilitating infections one can suffer from. Noroviruses are the most common causative agents of viral-associated gastroenteritis but unfortunately little is known regarding their biology and pathogenesis. Our study aims to investigate the replication and pathogenesis of a mouse norovirus to shed light on similar aspects relating to human norovirus infection. We aim to understand how virus infection in cells leads to disease symptoms.

Related publications (5)

Scholarly works icon

Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection

H Dubois, F Sorgeloos, ST Sarvestani, L Martens, Y Saeys, JM MacKenzie, M Lamkanfi, G Van Loo, I Goodfellow, A Wullaert

2019-01-01

Norovirus infection is the leading cause of food-borne gastroenteritis worldwide, being responsible for over 200,000 deaths annual..

Scholarly works icon

The norovirus NS3 protein is a dynamic lipid- and microtubule-associated protein involved in viral RNA replication

BT Cotton, JL Hyde, ST Sarvestani, SV Sosnovtsev, KY Green, PA White, JM Mackenzie

2017-01-01

Norovirus (NoV) infections are a significant health burden to society, yet the lack of reliable tissue culture systems has hampere..

Scholarly works icon

Mouse Norovirus infection promotes autophagy induction to facilitate replication but prevents final autophagosome maturation

TB O'Donnell, JL Hyde, JD Mintern, JM Mackenzie

2016-05-01

Autophagy is a cellular process used to eliminate intracellular pathogens. Many viruses however are able to manipulate this cellul..

Scholarly works icon

Nonnucleoside inhibitors of norovirus rna polymerase: Scaffolds for rational drug design

AA Eltahla, KL Lim, JS Eden, AG Kelly, JM Mackenzie, PA White

2014-01-01

Norovirus (NoV) is the leading cause of acute gastroenteritis worldwide, causing over 200,000 deaths a year. NoV is nonenveloped, ..

Scholarly works icon

Mouse norovirus 1 utilizes the cytoskeleton network to establish localization of the replication complex proximal to the microtubule organizing center

JL Hyde, LK Gillespie, JM Mackenzie

2012-04-01

Human noroviruses (family Caliciviridae) are the leading cause of nonbacterial gastroenteritis worldwide. Although Human norovirus..

University of Melbourne Researchers