Grant number: 631701 | Funding period: 2009 - 2014
Completed
nan
Vanessa Lakis, Rita T Lawlor, Felicity Newell, Ann-Marie Patch, Andrea Mafficini, Anguraj Sadanandam, Lambros T Koufariotis, Rebecca L Johnston, Conrad Leonard, Scott Wood, Borislav Rusev, Vincenzo Corbo, Claudio Luchini, Sara Cingarlini, Luca Landoni, Roberto Salvia, Michele Milella, David Chang, Peter Bailey, Nigel B Jamieson
2021-02-03
Here we report the DNA methylation profile of 84 sporadic pancreatic neuroendocrine tumors (PanNETs) with associated clinical and ..
Stephan B Dreyer, Rosie Upstill-Goddard, Viola Paulus-Hock, Clara Paris, Eirini-Maria Lampraki, Eloise Dray, Bryan Serrels, Giuseppina Caligiuri, Selma Rebus, Dennis Plenker, Zachary Galluzzo, Holly Brunton, Richard Cunningham, Mathias Tesson, Craig Nourse, Ulla-Maja Bailey, Marc Jones, Kim Moran-Jones, Derek W Wright, Fraser Duthie
2021-01-01
BACKGROUND & AIMS: Continuing recalcitrance to therapy cements pancreatic cancer (PC) as the most lethal malignancy, which is set ..
Holly Brunton, Giuseppina Caligiuri, Richard Cunningham, Rosie Upstill-Goddard, Ulla-Maja Bailey, Ian M Garner, Craig Nourse, Stephan Dreyer, Marc Jones, Kim Moran-Jones, Derek W Wright, Viola Paulus-Hock, Colin Nixon, Gemma Thomson, Nigel B Jamieson, Grant A McGregor, Lisa Evers, Colin J McKay, Aditi Gulati, Rachel Brough
2020-05-12
Pancreatic ductal adenocarcinoma (PDAC) can be divided into transcriptomic subtypes with two broad lineages referred to as classic..
Dale W Garsed, Kathryn Alsop, Sian Fereday, Catherine Emmanuel, Catherine J Kennedy, Dariush Etemadmoghadam, Bo Gao, Val Gebski, Valerie Gares, Elizabeth L Christie, Maartje CA Wouters, Katy Milne, Joshy George, Ann-Marie Patch, Jason Li, Gisela Mir Arnau, Timothy Semple, Sreeja R Gadipally, Yoke-Eng Chiew, Joy Hendley
2018-02-01
Purpose: Women with epithelial ovarian cancer generally have a poor prognosis; however, a subset of patients has an unexpected dra..
Dariush Etemadmoghadam, Walid J Azar, Ying Lei, Tania Moujaber, Dale W Garsed, Catherine J Kennedy, Sian Fereday, Chris Mitchell, Yoke-Eng Chiew, Joy Hendley, Raghwa Sharma, Paul R Harnett, Jason Li, Elizabeth L Christie, Ann-Marie Patch, Joshy George, George Au-Yeung, Gisela Mir Arnau, Timothy P Holloway, Timothy Semple
2017-08-15
Low-grade serous ovarian carcinomas (LGSC) are associated with a poor response to chemotherapy and are molecularly characterized b..
Amber L Johns, Skye H Mckay, Jeremy L Humphris, Mark Pinese, Lorraine A Chantrill, R Scott Mead, Katherine Tucker, Lesley Andrews, Annabel Goodwin, Conrad Leonard, Hilda A High, Katia Nones, Ann-Marie Patch, Neil D Merrett, Nick Pavlakis, Karin S Kassahn, Jaswinder S Samra, David K Miller, David K Chang, Marina Pajic
2017-04-28
BACKGROUND: The return of research results (RoR) remains a complex and well-debated issue. Despite the debate, actual data related..
Aldo Scarpa, David K Chang, Katia Nones, Vincenzo Corbo, Ann-Marie Patch, Peter Bailey, Rita T Lawlor, Amber L Johns, David K Miller, Andrea Mafficini, Borislav Rusev, Maria Scardoni, Davide Antonello, Stefano Barbi, Katarzyna O Sikora, Sara Cingarlini, Caterina Vicentini, Skye McKay, Michael CJ Quinn, Timothy JC Bruxner
2017-03-02
The diagnosis of pancreatic neuroendocrine tumours (PanNETs) is increasing owing to more sensitive detection methods, and this inc..
Rae-Anne Hardie, Ellen van Dam, Mark Cowley, Ting-Li Han, Seher Balaban, Marina Pajic, Mark Pinese, Mary Iconomou, Robert F Shearer, Jessie McKenna, David Miller, Nicola Waddell, John V Pearson, Sean M Grimmond, Leonid Sazanov, Andrew V Biankin, Silas Villas-Boas, Andrew J Hoy, Nigel Turner, Darren N Saunders
2017-01-30
BACKGROUND: Pancreatic cancer has a five-year survival rate of ~8%, with characteristic molecular heterogeneity and restricted tre..
Jeremy L Humphris, Ann-Marie Patch, Katia Nones, Peter J Bailey, Amber L Johns, Skye Mckay, David K Chang, David K Miller, Marina Pajic, Karin S Kassahn, Michael CJ Quinn, Timothy JC Bruxner, Angelika N Christ, Ivon Harliwong, Senel Idrisoglu, Suzanne Manning, Craig Nourse, Ehsan Nourbakhsh, Andrew Stone, Peter J Wilson
2017-01-01
Pancreatic cancer is molecularly diverse, with few effective therapies. Increased mutation burden and defective DNA repair are ass..
Lutz Krause, Katia Nones, Kelly A Loffler, Derek Nancarrow, Harald Oey, Yue Hang Tang, Nicola J Wayte, Ann Marie Patch, Kalpana Patel, Sandra Brosda, Suzanne Manning, Guy Lampe, Andrew Clouston, Janine Thomas, Jens Stoye, Damian J Hussey, David I Watson, Reginald V Lord, Wayne A Phillips, David Gotley
2016-04-01
The incidence of esophageal adenocarcinoma (EAC) has risen significantly over recent decades. Although survival has improved, cure..
Peter Bailey, David K Chang, Katia Nones, Amber L Johns, Ann-Marie Patch, Marie-Claude Gingras, David K Miller, Angelika N Christ, Tim JC Bruxner, Michael C Quinn, Craig Nourse, L Charles Murtaugh, Ivon Harliwong, Senel Idrisoglu, Suzanne Manning, Ehsan Nourbakhsh, Shivangi Wani, Lynn Fink, Oliver Holmes, Vencssa Chin
2016-03-03
Integrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32 recurrently mutated genes that aggregate into 1..
Marie-Claude Gingras, Kyle R Covington, David K Chang, Lawrence A Donehower, Anthony J Gill, Michael M Ittmann, Chad J Creighton, Amber L Johns, Eve Shinbrot, Ninad Dewal, William E Fisher, Christian Pilarsky, Robert Gruetzmann, Michael J Overman, Nigel B Jamieson, George Van Buren, Jennifer Drummond, Kimberly Walker, Oliver A Hampton, Liu Xi
2016-02-02
The ampulla of Vater is a complex cellular environment from which adenocarcinomas arise to form a group of histopathologically het..
JS Graham, NB Jamieson, R Rulach, SM Grimmond, DK Chang, AV Biankin
2015-09-01
The incidence of pancreatic ductal adenocarcinoma (PDAC) is steadily increasing and the annual death-to-incidence ratio approaches..
Ann-Marie Patch, Elizabeth L Christie, Dariush Etemadmoghadam, Dale W Garsed, Joshy George, Sian Fereday, Katia Nones, Prue Cowin, Kathryn Alsop, Peter J Bailey, Karin S Kassahn, Felicity Newell, Michael CJ Quinn, Stephen Kazakoff, Kelly Quek, Charlotte Wilhelm-Benartzi, Ed Curry, Huei San Leong, Anne Hamilton, Linda Mileshkin
2015-05-28
Patients with high-grade serous ovarian cancer (HGSC) have experienced little improvement in overall survival, and standard treatm..
Lorraine A Chantrill, Adnan M Nagrial, Clare Watson, Amber L Johns, Mona Martyn-Smith, Skye Simpson, Scott Mead, Marc D Jones, Jaswinder S Samra, Anthony J Gill, Nicole Watson, Venessa T Chin, Jeremy L Humphris, Angela Chou, Belinda Brown, Adrienne Morey, Marina Pajic, Sean M Grimmond, David K Chang, David Thomas
2015-05-01
PURPOSE: Personalized medicine strategies using genomic profiling are particularly pertinent for pancreas cancer. The Individualiz..
Nicola Waddell, Marina Pajic, Ann-Marie Patch, David K Chang, Karin S Kassahn, Peter Bailey, Amber L Johns, David Miller, Katia Nones, Kelly Quek, Michael CJ Quinn, Alan J Robertson, Muhammad ZH Fadlullah, Tim JC Bruxner, Angelika N Christ, Ivon Harliwong, Senel Idrisoglu, Suzanne Manning, Craig Nourse, Ehsan Nourbakhsh
2015-02-26
Pancreatic cancer remains one of the most lethal of malignancies and a major health burden. We performed whole-genome sequencing a..
Katia Nones, Nicola Waddell, Nicci Wayte, Ann-Marie Patch, Peter Bailey, Felicity Newell, Oliver Holmes, J Lynn Fink, Michael CJ Quinn, Yue Hang Tang, Guy Lampe, Kelly Quek, Kelly A Loffler, Suzanne Manning, Senel Idrisoglu, David Miller, Qinying Xu, Nick Waddell, Peter J Wilson, Timothy JC Bruxner
2014-10-01
Oesophageal adenocarcinoma (EAC) incidence is rapidly increasing in Western countries. A better understanding of EAC underpins eff..
Katia Nones, Nic Waddell, Sarah Song, Ann-Marie Patch, David Miller, Amber Johns, Jianmin Wu, Karin S Kassahn, David Wood, Peter Bailey, Lynn Fink, Suzanne Manning, Angelika N Christ, Craig Nourse, Stephen Kazakoff, Darrin Taylor, Conrad Leonard, David K Chang, Marc D Jones, Michelle Thomas
2014-09-01
The importance of epigenetic modifications such as DNA methylation in tumorigenesis is increasingly being appreciated. To define t..
Kelly Quek, Katia Nones, Ann-Marie Patch, J Lynn Fink, Felicity Newell, Nicole Cloonan, David Miller, Muhammad ZH Fadlullah, Karin Kassahn, Angelika N Christ, Timothy JC Bruxner, Suzanne Manning, Ivon Harliwong, Senel Idrisoglu, Craig Nourse, Ehsan Nourbakhsh, Shivangi Wani, Anita Steptoe, Matthew Anderson, Oliver Holmes
2014-07-01
Somatic rearrangements, which are commonly found in human cancer genomes, contribute to the progression and maintenance of cancers..
Angela Chou, Nicola Waddell, Mark J Cowley, Anthony J Gill, David K Chang, Ann-Marie Patch, Katia Nones, Jianmin Wu, Mark Pinese, Amber L Johns, David K Miller, Karin S Kassahn, Adnan M Nagrial, Harpreet Wasan, David Goldstein, Christopher W Toon, Venessa Chin, Lorraine Chantrill, Jeremy Humphris, R Scott Mead
2013-08-31
BACKGROUND: Pancreatic cancer is one of the most lethal and molecularly diverse malignancies. Repurposing of therapeutics that tar..
Andrew V Biankin, Nicola Waddell, Karin S Kassahn, Marie-Claude Gingras, Lakshmi B Muthuswamy, Amber L Johns, David K Miller, Peter J Wilson, Ann-Marie Patch, Jianmin Wu, David K Chang, Mark J Cowley, Brooke B Gardiner, Sarah Song, Ivon Harliwong, Senel Idrisoglu, Craig Nourse, Ehsan Nourbakhsh, Suzanne Manning, Shivangi Wani
2012-11-15
Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed exome sequencing and copy number analys..
Sarah Song, Katia Nones, David Miller, Ivon Harliwong, Karin S Kassahn, Mark Pinese, Marina Pajic, Anthony J Gill, Amber L Johns, Matthew Anderson, Oliver Holmes, Conrad Leonard, Darrin Taylor, Scott Wood, Qinying Xu, Felicity Newell, Mark J Cowley, Jianmin Wu, Peter Wilson, Lynn Fink
2012-09-25
Tumour cellularity, the relative proportion of tumour and normal cells in a sample, affects the sensitivity of mutation detection,..
Mark J Cowley, Mark Pinese, Karin S Kassahn, Nic Waddell, John V Pearson, Sean M Grimmond, Andrew V Biankin, Sampsa Hautaniemi, Jianmin Wu
2012-01-01
The Protein Interaction Network Analysis (PINA) platform is a comprehensive web resource, which includes a database of unified pro..
Rathi D Thiagarajan, Nicole Cloonan, Brooke B Gardiner, Tim R Mercer, Gabriel Kolle, Ehsan Nourbakhsh, Shivangi Wani, Dave Tang, Keerthana Krishnan, Kylie M Georgas, Bree A Rumballe, Han S Chiu, Jason A Steen, John S Mattick, Melissa H Little, Sean M Grimmond
2011-09-05
BACKGROUND: The developing mouse kidney is currently the best-characterized model of organogenesis at a transcriptional level. Det..
David LA Wood, Qinying Xu, John V Pearson, Nicole Cloonan, Sean M Grimmond
2011-02-15
SUMMARY: Accurate and complete mapping of short-read sequencing to a reference genome greatly enhances the discovery of biological..
Ryan Koehler, Hadar Issac, Nicole Cloonan, Sean M Grimmond
2011-01-15
SUMMARY: Quantification applications of short-tag sequencing data (such as CNVseq and RNAseq) depend on knowing the uniqueness of ..