DEVELOPING A BLOOD TEST FOR THE MOTHER TO DETERMINE WHETHER THE GROWTH RESTRICTED BABY IS UNWELL
Grant number: 1055795 | Funding period: 2013 - 2016
Small babies are at greater risk of dying while inside their mothers and the right time to deliver them is an obstetric conundrum. Currently obstetricians rely on ultrasound measures of the baby's wellbeing which do not always correspond with how sick the baby truly is. There is a great need for a more accurate test. This research intends to show that a blood test from the mother can more accurately tell how sick the baby is and provide an answer to when is the best time to deliver the baby.
Related publications (4)
Circulating mRNAs are differentially expressed in pregnancies with severe placental insufficiency and at high risk of stillbirth
Natalie J Hannan, Owen Stock, Rebecca Spencer, Clare Whitehead, Anna L David, Katie Groom, Scott Petersen, Amanda Henry, Joanne M Said, Sean Seeho, Stefan C Kane, Lavinia Gordon, Sally Beard, Kantaraja Chindera, Smita Karegodar, Richard Hiscock, Natasha Pritchard, Tu'uhevaha J Kaitu'u-Lino, Susan P Walker, Stephen Tong
Background Fetuses affected by placental insufficiency do not receive adequate nutrients and oxygenation, become growth restricted..
Chorioamnionitis Occurring in Women With Preterm Rupture of the Fetal Membranes Is Associated With a Dynamic Increase in mRNAs Coding Cytokines in the Maternal Circulation
Owen Stock, Lavinia Gordon, Jada Kapoor, Susan P Walker, Clare Whitehead, Tu'uhevaha J Kaitu'u-Lino, Gabrielle Pell, Natalie J Hannan, Stephen Tong
BACKGROUND: Preterm prelabor rupture of the fetal membranes (PPROM) is a significant contributor to the morbidity and mortality of..
Placental SEMA3B expression is not altered in severe early onset preeclampsia
TJ Kaitu'u-Lino, R Hastie, P Cannon, NK Binder, S Lee, O Stock, NJ Hannan, S Tong
Recent evidence suggests that Semaphorin 3B (SEMA3B) is upregulated in severe preeclampsia, and a major driver of cytotrophoblast ..
Stability of absolute copy number of housekeeping genes in preeclamptic and normal placentas, as measured by digital PCR
TJ Kaitu'u-Lino, R Hastie, P Cannon, S Lee, O Stock, NJ Hannan, R Hiscock, S Tong
Measuring mRNA expression is fundamental to placental research. Ideally, mRNA transcript numbers are directly quantified. However,..