CENTRE OF RESEARCH EXCELLENCE FOR PROBE-NET: THE PROGRESSION OF BARRETT'S ESOPHAGUS TO CANCER NETWORK
Grant number: 1040947 | Funding period: 2013 - 2017
This application brings together the seven major research teams in Australia with expertise in oesophageal neoplasia to form a multi-state, multi-disciplinary Centre for Research Excellence. All of the nodes have worked together collaboratively for the past 4 years, pooling their expertise in surgery, gastroenterology, endoscopy, epidemiology, biostatistics, basic science, health policy and translational research. Our vision is to develop evidence-based strategies for reducing the burden of oesophageal neoplasia.
Related publications (5)
The prognostic value of TP53 mutations in oesophageal adenocarcinoma: a systematic review and meta-analysis
Oliver M Fisher, Sarah J Lord, Dan Falkenback, Nicholas J Clemons, Guy D Eslick, Reginald V Lord
OBJECTIVE: To clarify the prognostic role of tumour protein 53 (TP53) mutations in patients with oesophageal adenocarcinoma (OAC) ..
Inhibiting system x(C)(-) and glutathione biosynthesis - a potential Achilles' heel in mutant-p53 cancers
Nicholas J Clemons, David S Liu, Cuong P Duong, Wayne A Phillips
Effective therapeutic strategies to target mutant tumor protein p53 (TP53, best known as p53) cancers remain an unmet medical need..
The Genetics of Barrett's Esophagus: A Familial and Population-Based Perspective
Henry To, Nicholas J Clemons, Cuong P Duong, Alison H Trainer, Wayne A Phillips
Barrett's esophagus (BE) is intestinal metaplasia of the lower esophagus and a precursor lesion for esophageal adenocarcinoma (EAC..
Intramuscular Transplantation Improves Engraftment Rates for Esophageal Patient-Derived Tumor Xenografts
Matthew Read, David Liu, Cuong P Duong, Carleen Cullinane, William K Murray, Christina M Fennell, Jake Shortt, David Westerman, Paul Burton, Nicholas J Clemons, Wayne A Phillips
BACKGROUND: Recently, there has been an increase in the availability of targeted molecular therapies for cancer treatment. The app..