CENTRE OF RESEARCH EXCELLENCE FOR PROBE-NET: THE PROGRESSION OF BARRETT'S ESOPHAGUS TO CANCER NETWORK

Grant number: 1040947 | Funding period: 2013 - 2017

Completed

Abstract

This application brings together the seven major research teams in Australia with expertise in oesophageal neoplasia to form a multi-state, multi-disciplinary Centre for Research Excellence. All of the nodes have worked together collaboratively for the past 4 years, pooling their expertise in surgery, gastroenterology, endoscopy, epidemiology, biostatistics, basic science, health policy and translational research. Our vision is to develop evidence-based strategies for reducing the burden of oesophageal neoplasia.

Related publications (5)

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OBJECTIVE: To clarify the prognostic role of tumour protein 53 (TP53) mutations in patients with oesophageal adenocarcinoma (OAC) ..

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Inhibiting system x(C)(-) and glutathione biosynthesis - a potential Achilles' heel in mutant-p53 cancers

Nicholas J Clemons, David S Liu, Cuong P Duong, Wayne A Phillips

2017-01-01

Effective therapeutic strategies to target mutant tumor protein p53 (TP53, best known as p53) cancers remain an unmet medical need..

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Preclinical Models of Esophageal Adenocarcinoma for Drug Development

David S Liu, Cuong P Duong, Wayne A Phillips, Nicholas J Clemons

2016-12-01

The advent of multi-omic profiling of tumors, together with the increasing affordability of high-throughput drug screening program..

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The Genetics of Barrett's Esophagus: A Familial and Population-Based Perspective

Henry To, Nicholas J Clemons, Cuong P Duong, Alison H Trainer, Wayne A Phillips

2016-07-01

Barrett's esophagus (BE) is intestinal metaplasia of the lower esophagus and a precursor lesion for esophageal adenocarcinoma (EAC..

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Intramuscular Transplantation Improves Engraftment Rates for Esophageal Patient-Derived Tumor Xenografts

Matthew Read, David Liu, Cuong P Duong, Carleen Cullinane, William K Murray, Christina M Fennell, Jake Shortt, David Westerman, Paul Burton, Nicholas J Clemons, Wayne A Phillips

2016-01-01

BACKGROUND: Recently, there has been an increase in the availability of targeted molecular therapies for cancer treatment. The app..

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