Long Term Effects of Alcohol Exposure in Early Development

Grant number: 1046137 | Funding period: 2013 - 2015

Completed

Abstract

It is known that consuming large amounts of alcohol during pregnancy can have deleterious effects on fetal growth and development. Less is known about the effects of consumption of alcohol just around the time of conception. This project will use animal models to explore if alcohol can alter development of the very early embryo and whether this has long term consequences for the health of offspring after birth.

Related publications (4)

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Periconceptional alcohol alters in vivo heart function in ageing female rat offspring: Possible involvement of oestrogen receptor signalling

ES Dorey, JP Headrick, TM Paravicini, ME Wlodek, KM Moritz, ME Reichelt

2023-05-01

New Findings: What is the central question of this study? What are the cardiovascular consequences of periconceptual ethanol on of..

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Role of fetal programming and epigenetic regulation on the development of endocrine and metabolic alterations: Effects of periconceptional maternal alcohol intake and a postnatal high-fat diet on obesity and liver disease in male and female rat offspring

EM Gårdebjer, JSM Cuffe, LC Ward, S Steane, ST Anderson, ES Dorey, JI Kalisch-Smith, M Pantaleon, S Chong, L Yamada, ME Wlodek, H Bielefeldt-Ohmann, KM Moritz

2018-10-08

The effects of maternal alcohol consumption around the time of conception on offspring are largely unknown and difficult to determ..

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Maternal alcohol intake around the time of conception causes glucose intolerance and insulin insensitivity in rat offspring, which is exacerbated by a postnatal high-fat diet

EM Gårdebjer, ST Anderson, M Pantaleon, ME Wlodek, KM Moritz

2015-07-01

Alcohol consumption throughout pregnancy can cause metabolic dysregulation, including glucose intolerance in progeny. This study d..

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Periconceptional alcohol consumption causes fetal growth restriction and increases glycogen accumulation in the late gestation rat placenta

EM Gårdebjer, JSM Cuffe, M Pantaleon, ME Wlodek, KM Moritz

2014-01-01

Introduction Alcohol consumption is a common social practice among women of childbearing age. With 50% of pregnancies being unplan..

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