Oncogenic Signaling And Cancer Therapy
Grant number: 1053792 | Funding period: 2014 - 2018
Central to improving the management of patients with cancer is an understanding of the molecular drivers of cancer. Based on our fundamental discoveries about the role of cell growth and perturbed cell signalling as drivers of cancer we will use the integration of molecular and imaging biomarkers with targeted therapies to translate this knowledge into better outcomes for cancer patients with defined molecular drivers of their cancer.
Related publications (22)
Neurokinin-1 receptor is an effective target for treating leukemia by inducing oxidative stress through mitochondrial calcium overload
Chentao Ge, Hemiao Huang, Feiyan Huang, Tianxin Yang, Tengfei Zhang, Hongzhang Wu, Hanwei Zhou, Qi Chen, Yue Shi, Yanfang Sun, Liangjue Liu, Xi Wang, Richard B Pearson, Yihai Cao, Jian Kang, Caiyun Fu
Inhibition of RNA Polymerase I Transcription Activates Targeted DNA Damage Response and Enhances the Efficacy of PARP Inhibitors in High-Grade Serous Ovarian Cancer
Elaine Sanij, Katherine Hannan, Shunfei Yan, Jiachen Xuan, Jessica Ahern, Keefe Chan, Jinbae Son, Olga Kondrashova, Elizabeth Lieschke, Matthew Wakefield, Anna Trigos, Daniel Frank, Sarah Ellis, Carleen Cullinane, Jian Kang, Gretchen Poortinga, Purba Nag, Kum Kum Khanna, Linda Mileshkin, Grant McArthur
Abstract High-grade serous ovarian cancer (HGSOC) accounts for the majority of ovarian cancer and has a dismal prognosis. PARP inh..
Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation.
Jeannine Diesch, Megan J Bywater, Elaine Sanij, Donald P Cameron, William Schierding, Natalie Brajanovski, Jinbae Son, Jirawas Sornkom, Nadine Hein, Maurits Evers, Richard B Pearson, Grant A McArthur, Austen RD Ganley, Justin M O'Sullivan, Ross D Hannan, Gretchen Poortinga
The three-dimensional organization of the genome contributes to its maintenance and regulation. While chromosomal regions associat..
Somatic mutations in early metazoan genes disrupt regulatory links between unicellular and multicellular genes in cancer
Anna Trigos, Rick Pearson, Anthony Papenfuss, David Goode
Extensive transcriptional alterations are observed in cancer, many of which activate core biological processes established in unic..
TERT structural rearrangements in metastatic pheochromocytomas
Trisha Dwight, Aidan Flynn, Kaushalya Amarasinghe, Diana E Benn, Richard Lupat, Jason Li, Daniel L Cameron, Annette Hogg, Shiva Balachander, Ida LM Candiloro, Stephen Q Wong, Bruce G Robinson, Anthony T Papenfuss, Anthony J Gill, Alexander Dobrovic, Rodney J Hicks, Roderick J Clifton-Bligh, Richard W Tothill
Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population
Nadine Hein, Donald P Cameron, Katherine M Hannan, Nhu-Y N Nguyen, Chun Yew Fong, Jirawas Sornkom, Meaghan Wall, Megan Pavy, Carleen Cullinane, Jeannine Diesch, Jennifer R Devlin, Amee J George, Elaine Sanij, Jaclyn Quin, Gretchen Poortinga, Inge Verbrugge, Adele Baker, Denis Drygin, Simon J Harrison, James D Rozario
Cell cycle and growth stimuli regulate different steps of RNA polymerase I transcription
Sandy S Hung, Analia Lesmana, Abigail Peck, Rachel Lee, Elly Tchoubrieva, Katherine M Hannan, Jane Lin, Karen E Sheppard, Katarzyna Jastrzebski, Leonie M Quinn, Lawrence I Rothblum, Richard B Pearson, Ross D Hannan, Elaine Sanij
Circulating Tumor DNA Analysis and Functional Imaging Provide Complementary Approaches for Comprehensive Disease Monitoring in Metastatic Melanoma
Stephen Q Wong, Jeanette M Raleigh, Jason Callahan, Ismael A Vergara, Sarah Ftouni, Athena Hatzimihalis, Andrew J Colebatch, Jason Li, Timothy Semple, Kenneth Doig, Christopher Mintoff, Devbarna Sinha, Paul Yeh, Maria Joao Silva, Kathryn Alsop, Heather Thorne, David D Bowtell, David E Gyorki, Gisela Mir Arnau, Carleen Cullinane
The Dual Inhibition of RNA Pol I Transcription and PIM Kinase as a New Therapeutic Approach to Treat Advanced Prostate Cancer
Richard J Rebello, Eric Kusnadi, Donald P Cameron, Helen B Pearson, Analia Lesmana, Jennifer R Devlin, Denis Drygin, Ashlee K Clark, Laura Porter, John Pedersen, Shahneen Sandhu, Gail P Risbridger, Richard B Pearson, Ross D Hannan, Luc Furic
Clustered somatic mutations are frequent in transcription factor binding motifs within proximal promoter regions in melanoma and other cutaneous malignancies
Andrew J Colebatch, Leon Di Stefano, Stephen Q Wong, Ross D Hannan, Paul M Waring, Alexander Dobrovic, Grant A McArthur, Anthony T Papenfuss
Combining High-Content Imaging and Phenotypic Classification Analysis of Senescence-Associated Beta-Galactosidase Staining to Identify Regulators of Oncogene-Induced Senescence
Keefe T Chan, Lassi Paavolainen, Katherine M Hannan, Amee J George, Ross D Hannan, Kaylene J Simpson, Peter Horvath, Richard B Pearson
Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling
Jaclyn Quin, Keefe T Chan, Jennifer R Devlin, Donald P Cameron, Jeannine Diesch, Carleen Cullinane, Jessica Ahern, Amit Khot, Nadine Hein, Amee J George, Katherine M Hannan, Gretchen Poortinga, Karen E Sheppard, Kum Kum Khanna, Ricky W Johnstone, Denis Drygin, Grant A McArthur, Richard B Pearson, Elaine Sanij, Ross D Hannan
Desmoglein 2 promotes vasculogenic mimicry in melanoma and is associated with poor clinical outcome
Lih Yin Tan, Chris Mintoff, M Zahied Johan, Brenton W Ebert, Clare Fedele, You Fang Zhang, Pacman Szeto, Karen E Sheppard, Grant A McArthur, Erwin Foster-Smith, Andrew Ruszkiewicz, Michael P Brown, Claudine S Bonder, Mark Shackleton, Lisa M Ebert
Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma
Jennifer R Devlin, Katherine M Hannan, Nadine Hein, Carleen Cullinane, Eric Kusnadi, Pui Yee Ng, Amee J George, Jake Shortt, Megan J Bywater, Gretchen Poortinga, Elaine Sanij, Jian Kang, Denis Drygin, Sean O'Brien, Ricky W Johnstone, Grant A McArthur, Ross D Hannan, Richard B Pearson
Whole exome sequencing identifies a recurrent RQCD1 P131L mutation in cutaneous melanoma
SQ Wong, A Behren, VJ Mar, K Woods, J Li, C Martin, KE Sheppard, R Wolfe, J Kelly, J Cebon, A Dobrovic, GA McArthur
Melanoma is often caused by mutations due to exposure to ultraviolet radiation. This study reports a recurrent somatic C > T chang..