LYMPHATIC BIOLOGY IN HUMAN DISEASE

Grant number: 1053535 | Funding period: 2014 - 2018

Completed

Abstract

This proposal is for a team of researchers and clinicians to explore the molecular control of the lymphatic vasculature. This network of lymphatic vessels, located in organs throughout the body, is critical for regulation of tissue fluid and immune function. It will identify new molecular pathways controlling lymphatic vessels and their interactions with other cells in the body and identify new diagnostic approaches and molecular targets for medicines to treat human diseases including cancer.

Related publications (4)

The evolving role of lymphatics in cancer metastasis

Rae H Farnsworth, Marc G Achen, Steven A Stacker

2018-08-01

The Role of the Tumor vasculature in the Host immune Response: implications for Therapeutic Strategies Targeting the Tumor Microenvironment

Shona A Hendry, Rae H Farnsworth, Benjamin Solomon, Marc G Achen, Steven A Stacker, Stephen B Fox

2016-12-20

Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination

Caroline P Le, Cameron J Nowell, Corina Kim-Fuchs, Edoardo Botteri, Jonathan G Hiller, Hilmy Ismail, Matthew A Pimentel, Ming G Chai, Tara Karnezis, Nicole Rotmensz, Giuseppe Renne, Sara Gandini, Colin W Pouton, Davide Ferrari, Andreas Moeller, Steven A Stacker, Erica K Sloan

2016-03-01