LYMPHATIC BIOLOGY IN HUMAN DISEASE

Pkd1 and Wnt5a genetically interact to control lymphatic vascular morphogenesis in mice

Tevin CY Chau, Sungmin Baek, Baptiste Coxam, Renae Skoczylas, Maria Rondon-Galeano, Neil I Bower, Elanor N Wainwright, Steven A Stacker, Helen M Cooper, Peter A Koopman, Anne K Lagendijk, Natasha L Harvey, Mathias Francois, Benjamin M Hogan

2021-07-16

BACKGROUND: Lymphatic vascular development is regulated by well-characterized signaling and transcriptional pathways. These pathwa..

Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy

Michael Y He, Michael M Halford, Ruofei Liu, James P Roy, Zoe L Grant, Leigh Coultas, Niko Thio, Omer Gilan, Yih-Chih Chan, Mark A Dawson, Marc G Achen, Steven A Stacker

2021-07-15

Angiogenesis underlies development, physiology and pathogenesis of cancer, eye and cardiovascular diseases. Inhibiting aberrant an..

The Interplay Between Lymphatic Vessels and Chemokines

Rae H Farnsworth, Tara Karnezis, Simon J Maciburko, Scott N Mueller, Steven A Stacker

2019-04-12

Chemokines are a family of small protein cytokines that act as chemoattractants to migrating cells, in particular those of the imm..

CCL27/CCL28-CCR10 Chemokine Signaling Mediates Migration of Lymphatic Endothelial Cells

Tara Karnezis, Rae H Farnsworth, Nicole C Harris, Steven P Williams, Carol Caesar, David J Byrne, Prad Herle, Maria L Macheda, Ramin Shayan, You-Fang Zhang, Sezer Yazar, Simon J Takouridis, Craig Gerard, Stephen B Fox, Marc G Achen, Steven A Stacker

2019-04-01

Metastasis via the lymphatic vasculature is an important step in cancer progression. The formation of new lymphatic vessels (lymph..

The evolving role of lymphatics in cancer metastasis

Rae H Farnsworth, Marc G Achen, Steven A Stacker

2018-08-01

While the link between the lymphatic system and the metastatic spread of cancer is centuries old, understanding of the underlying ..

Emerging Roles for VEGF-D in Human Disease

Steven A Stacker, Marc G Achen

2018-03-01

Blood vessels and lymphatic vessels are located in many tissues and organs throughout the body, and play important roles in a wide..

Genome-wide functional analysis reveals central signaling regulators of lymphatic endothelial cell migration and remodeling

Steven P Williams, Adam F Odell, Tara Karnezis, Rae H Farnsworth, Cathryn M Gould, Jason Li, Sophie Paquet-Fifield, Nicole C Harris, Anne Walter, Julia L Gregory, Sara F Lamont, Ruofei Liu, Elena A Takano, Cameron J Nowell, Neil I Bower, Daniel Resnick, Gordon K Smyth, Leigh Coultas, Benjamin M Hogan, Stephen B Fox

2017-10-03

Lymphatic vessels constitute a specialized vasculature that is involved in development, cancer, obesity, and immune regulation. Th..

Vegfd modulates both angiogenesis and lymphangiogenesis during zebrafish embryonic development

Neil I Bower, Adam J Vogrin, Ludovic Le Guen, Huijun Chen, Steven A Stacker, Marc G Achen, Benjamin M Hogan

2017-02-01

Vascular endothelial growth factors (VEGFs) control angiogenesis and lymphangiogenesis during development and in pathological cond..

The fibrinolysis inhibitor alpha(2)-antiplasmin restricts lymphatic remodelling and metastasis in a mouse model of cancer

Sophie Paquet-Fifield, Sally Roufail, You-Fang Zhang, Trifina Sofian, David J Byrne, Paul B Coughlin, Stephen B Fox, Steven A Stacker, Marc G Achen

2017-01-01

Remodelling of lymphatic vessels in tumours facilitates metastasis to lymph nodes. The growth factors VEGF-C and VEGF-D are well k..

The Role of the Tumor vasculature in the Host immune Response: implications for Therapeutic Strategies Targeting the Tumor Microenvironment

Shona A Hendry, Rae H Farnsworth, Benjamin Solomon, Marc G Achen, Steven A Stacker, Stephen B Fox

2016-12-20

Recently developed cancer immunotherapy approaches including immune checkpoint inhibitors and chimeric antigen receptor T cell tra..

Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination

Caroline P Le, Cameron J Nowell, Corina Kim-Fuchs, Edoardo Botteri, Jonathan G Hiller, Hilmy Ismail, Matthew A Pimentel, Ming G Chai, Tara Karnezis, Nicole Rotmensz, Giuseppe Renne, Sara Gandini, Colin W Pouton, Davide Ferrari, Andreas Moeller, Steven A Stacker, Erica K Sloan

2016-03-01

Chronic stress induces signalling from the sympathetic nervous system (SNS) and drives cancer progression, although the pathways o..

Expression and purification of bioactive, low-endotoxin recombinant human vitronectin

Michael M Halford, Yi-Chao He, Steven A Stacker

2014-06-01

The secreted adhesive glycoprotein vitronectin (VTN) is a multifunctional component of plasma and the extracellular matrix. A high..