Systems biology of asthma development in early childhood
Grant number: 1049539 | Funding period: 2013 - 2016
Recent studies have established that both human genetic susceptibility and viral infections during early childhood are important drivers of asthma development. It has also been noted that asthmatics’ airways are colonized with different bacteria to non-asthmatics. In this project we will examine how genetic susceptibility and interactions between bacteria and viruses in children's airways promote the development of allergy and asthma.
Related publications (6)
Developmental patterns in the nasopharyngeal microbiome during infancy are associated with asthma risk
Howard HF Tang, Anna Lang, Shu Mei Teo, Louise M Judd, Ronald Gangnon, Michael D Evans, Kristine E Lee, Rose Vrtis, Patrick G Holt, Robert F Lemanske, Daniel J Jackson, Kathryn E Holt, Michael Inouye, James E Gern
BACKGROUND: Studies indicate that the nasal microbiome may correlate strongly with the presence or future risk of childhood asthma..
Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk
Qin Qin Huang, Howard HF Tang, Shu Mei Teo, Danny Mok, Scott C Ritchie, Artika P Nath, Marta Brozynska, Agus Salim, Andrew Bakshi, Barbara J Holt, Chiea Chuen Khor, Peter D Sly, Patrick G Holt, Kathryn E Holt, Michael Inouye
Chronic immune-mediated diseases of adulthood often originate in early childhood. To investigate genetic associations between neon..
Trajectories of childhood immune development and respiratory health relevant to asthma and allergy.
Howard Hf Tang, Shu Mei Teo, Danielle Cm Belgrave, Michael D Evans, Daniel J Jackson, Marta Brozynska, Merci Mh Kusel, Sebastian L Johnston, James E Gern, Robert F Lemanske, Angela Simpson, Adnan Custovic, Peter D Sly, Patrick G Holt, Kathryn E Holt, Michael Inouye
Events in early life contribute to subsequent risk of asthma; however, the causes and trajectories of childhood wheeze are heterog..
Airway Microbiota Dynamics Uncover a Critical Window for Interplay of Pathogenic Bacteria and Allergy in Childhood Respiratory Disease
Shu Mei Teo, Howard HF Tang, Danny Mok, Louise M Judd, Stephen C Watts, Kym Pham, Barbara J Holt, Merci Kusel, Michael Serralha, Niamh Troy, Yury A Bochkov, Kristine Grindle, Robert F Lemanske, Sebastian L Johnston, James E Gern, Peter D Sly, Patrick G Holt, Kathryn E Holt, Michael Inouye
Repeated cycles of infection-associated lower airway inflammation drive the pathogenesis of persistent wheezing disease in childre..
The Infant Nasopharyngeal Microbiome Impacts Severity of Lower Respiratory Infection and Risk of Asthma Development
Shu Mei Teo, Danny Mok, Kym Pham, Merci Kusel, Michael Serralha, Niamh Troy, Barbara J Holt, Belinda J Hales, Michael L Walker, Elysia Hollams, Yury A Bochkov, Kristine Grindle, Sebastian L Johnston, James E Gern, Peter D Sly, Patrick G Holt, Kathryn E Holt, Michael Inouye
The nasopharynx (NP) is a reservoir for microbes associated with acute respiratory infections (ARIs). Lung inflammation resulting ..
Elucidation of pathways driving asthma pathogenesis: development of a systems-level analytic strategy
Michael L Walker, Kathryn E Holt, Gary P Anderson, Shu Mei Teo, Peter D Sly, Patrick G Holt, Michael Inouye
Asthma is a genetically complex, chronic lung disease defined clinically as episodic airflow limitation and breathlessness that is..