Pathogenesis and therapeutic modulation of aggressive behaviour in a mouse model of autism spectrum disorder

Gastrointestinal dysfunction in patients and mice expressing the autism-associated R451C mutation in neuroligin-3

Suzanne Hosie, Melina Ellis, Mathusi Swaminathan, Fatima Ramalhosa, Gracia O Seger, Gayathri K Balasuriya, Christopher Gillberg, Maria Rastam, Leonid Churilov, Sonja J McKeown, Nalzi Yalcinkaya, Petri Urvil, Tor Savidge, Carolyn A Bell, Oonagh Bodin, Jen Wood, Ashley E Franks, Joel C Bornstein, Elisa L Hill-Yardin

2019-07-01

Gastrointestinal (GI) problems constitute an important comorbidity in many patients with autism. Multiple mutations in the neuroli..

Altered Amygdala Excitation and CB1 Receptor Modulation of Aggressive Behavior in the Neuroligin-3(R451C) Mouse Model of Autism

Suzanne Hosie, Daniel T Malone, Stephanie Liu, Michelle Glass, Paul Anthony Adlard, Anthony John Hannan, Elisa L Hill-Yardin

2018-08-03

Understanding neuronal mechanisms underlying aggression in patients with autism spectrum disorder (ASD) could lead to better treat..

What's wrong with my mouse cage? Methodological considerations for modeling lifestyle factors and gene-environment interactions in mice

Christina Mo, Thibault Renoir, Anthony J Hannan

2016-05-30

The mechanistic understanding of lifestyle contributions to disease has been largely driven by work in laboratory rodent models us..

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

EL Hill-Yardin, null Swaminathan M, null Ellis M, null Zygorodimos M, null Johnston LA, null Gwynne RM, null Bornstein JC

2016-02-01

The enteric nervous system (ENS) plays an important role in regulating gastrointestinal (GI) motility and can function independent..

A neuroligin-3 mutation implicated in autism causes abnormal aggression and increases repetitive behavior in mice

Emma L Burrows, Liliana Laskaris, Lynn Koyama, Leonid Churilov, Joel C Bornstein, Elisa L Hill-Yardin, Anthony J Hannan

2015-11-14

BACKGROUND: Aggression is common in patients with autism spectrum disorders (ASD) along with the core symptoms of impairments in s..

Reduced susceptibility to induced seizures in the Neuroligin-3(R451C) mouse model of autism

Elisa L Hill-Yardin, Andrew Argyropoulos, Suzanne Hosie, Gil Rind, Paul Anderson, Anthony J Hannan, Terence J O'Brien

2015-03-04

Epilepsy is a common comorbidity in patients with autism spectrum disorder (ASD) and several gene mutations are associated with bo..

Translating Preclinical Environmental Enrichment Studies for the Treatment of Autism and Other Brain Disorders: Comment on Woo and Leon (2013)

Elisa L Hill-Yardin, Anthony J Hannan

2013-08-01

Environmental enrichment (EE) has been shown to induce beneficial effects in mouse models of autism spectrum disorder (ASD), as we..

Studying autism in rodent models: reconciling endophenotypes with comorbidities

Andrew Argyropoulos, Krista L Gilby, Elisa L Hill-Yardin

2013-07-25

Autism spectrum disorder (ASD) patients commonly exhibit a variety of comorbid traits including seizures, anxiety, aggressive beha..

Characterizing social behavior in genetically targeted mouse models of brain disorders.

Emma L Burrows, Anthony J Hannan

2013-01-01

Fragile X syndrome, the leading inherited cause of mental retardation and autism spectrum disorders worldwide, is caused by a tand..