Pathogenesis and therapeutic modulation of aggressive behaviour in a mouse model of autism spectrum disorder
Grant number: 1047674 | Funding period: 2013 - 2015
This project focuses on understanding the causes of aggressive behaviour in mice that have a human gene mutation found in autism. Aggressive behaviour is common in autism patients and can have severe consequences on education and employment opportunities. These mice also show excess dampening of brain function (inhibition). This project will test if aggression in these mice is caused by altered inhibition.
Related publications (8)
Gastrointestinal dysfunction in patients and mice expressing the autism-associated R451C mutation in neuroligin-3
Suzanne Hosie, Melina Ellis, Mathusi Swaminathan, Fatima Ramalhosa, Gracia O Seger, Gayathri K Balasuriya, Christopher Gillberg, Maria Rastam, Leonid Churilov, Sonja J McKeown, Nalzi Yalcinkaya, Petri Urvil, Tor Savidge, Carolyn A Bell, Oonagh Bodin, Jen Wood, Ashley E Franks, Joel C Bornstein, Elisa L Hill-Yardin
Gastrointestinal (GI) problems constitute an important comorbidity in many patients with autism. Multiple mutations in the neuroli..
Altered Amygdala Excitation and CB1 Receptor Modulation of Aggressive Behavior in the Neuroligin-3(R451C) Mouse Model of Autism
Suzanne Hosie, Daniel T Malone, Stephanie Liu, Michelle Glass, Paul Anthony Adlard, Anthony John Hannan, Elisa L Hill-Yardin
Understanding neuronal mechanisms underlying aggression in patients with autism spectrum disorder (ASD) could lead to better treat..
What's wrong with my mouse cage? Methodological considerations for modeling lifestyle factors and gene-environment interactions in mice
Christina Mo, Thibault Renoir, Anthony J Hannan
The mechanistic understanding of lifestyle contributions to disease has been largely driven by work in laboratory rodent models us..
A neuroligin-3 mutation implicated in autism causes abnormal aggression and increases repetitive behavior in mice
Emma L Burrows, Liliana Laskaris, Lynn Koyama, Leonid Churilov, Joel C Bornstein, Elisa L Hill-Yardin, Anthony J Hannan
BACKGROUND: Aggression is common in patients with autism spectrum disorders (ASD) along with the core symptoms of impairments in s..
Reduced susceptibility to induced seizures in the Neuroligin-3(R451C) mouse model of autism
Elisa L Hill-Yardin, Andrew Argyropoulos, Suzanne Hosie, Gil Rind, Paul Anderson, Anthony J Hannan, Terence J O'Brien
Epilepsy is a common comorbidity in patients with autism spectrum disorder (ASD) and several gene mutations are associated with bo..
Translating Preclinical Environmental Enrichment Studies for the Treatment of Autism and Other Brain Disorders: Comment on Woo and Leon (2013)
Elisa L Hill-Yardin, Anthony J Hannan
Environmental enrichment (EE) has been shown to induce beneficial effects in mouse models of autism spectrum disorder (ASD), as we..