THE INTERACTION BETWEEN THE HOST AND PATHOGEN GENETICS IN SUSCEPTIBILITY TO PULMONARY TUBERCOLOSIS
Grant number: 1056689 | Funding period: 2013 - 2016
People infected with the bacteria causing tuberculosis (TB) have different clinical fates. Some people remain well with dormant infections, some get lung disease and survive, others die. We are investigating the interplay between the human host and the bacteria causing disease by identifying genetic variants in both. This will enable us to determine what is important in the defence against this disease. Knowledge of the different TB disease processes is critical for future rational design of new TB vaccines and treatments.
Related publications (4)
Sources of Multidrug Resistance in Patients With Previous Isoniazid-Resistant Tuberculosis Identified Using Whole Genome Sequencing: A Longitudinal Cohort Study
Vijay Srinivasan, Vu TN Ha, Dao N Vinh, Phan VK Thai, Dang TM Ha, Nguyen H Lan, Hoang T Hai, Timothy M Walker, Do DA Thu, Sarah J Dunstan, Guy E Thwaites, Philip M Ashton, Maxine Caws, Nguyen TT Thuong
BACKGROUND: Meta-analysis of patients with isoniazid-resistant tuberculosis (TB) given standard first-line anti-TB treatment indic..
Empirical ways to identify novel Bedaquiline resistance mutations in AtpE
Malancha Karmakar, Carlos HM Rodrigues, Kathryn E Holt, Sarah J Dunstan, Justin Denholm, David B Ascher
Clinical resistance against Bedaquiline, the first new anti-tuberculosis compound with a novel mechanism of action in over 40 year..
Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam
Kathryn E Holt, Paul McAdam, Vuong Khac Thai Phan, Thuy Thuong Thuong Nguyen, Thi Minh Ha Dang, Ngoc Lan Nguyen, Huu Lan Nguyen, Thi Quynh Nhu Nguyen, Thanh Hai Hoang, Thi Ngoc Ha Vu, Guy Thwaites, David J Edwards, Artika P Nath, Kym Pham, David B Ascher, Jeremy Farrar, Chiea Chuen Khor, Yik Ying Teo, Michael Inouye, Maxine Caws
To examine the transmission dynamics of Mycobacterium tuberculosis (Mtb) isolated from tuberculosis patients in Ho Chi Minh City, ..
GeneXpert MTB/Rif to Diagnose Tuberculous Meningitis: Perhaps the First Test but not the Last.
Nathan C Bahr, Suzaan Marais, Maxine Caws, Reinout van Crevel, Robert J Wilkinson, Jaya S Tyagi, Guy E Thwaites, David R Boulware, null Tuberculous Meningitis International Research Consortium
Tuberculous meningitis (TBM) is the most severe form of tuberculous with substantial mortality. In May 2015, 54 researchers from 1..