SURFACE ANTIGENS AOF PLASMODIUM FALCIPARUM-INFECTED ERYTHOCYTES AND IMMUNITY TO MALARIA IN HUMANS

Grant number: 1047715 | Funding period: 2013 - 2015

Completed

Abstract

Malaria is a leading cause of death globally, particularly among children. Malaria parasites infect red blood cells and multiply inside them, resulting in severe illness if left untreated. Effective treatments are limited and currently there is no vaccine. In human studies, we aim to identify the target antigens of immune responses and immune mechanisms that protect against malaria. With this knowledge, vaccines can be designed against malaria to prevent serious illness and death.

Related publications (5)

Scholarly works icon

P. falciparum infection and maternofetal antibody transfer in malaria-endemic settings of varying transmission

Alistair RD McLean, Danielle Stanisic, Rose McGready, Kesinee Chotivanich, Caroline Clapham, Francesca Baiwog, Mupawjay Pimanpanarak, Peter Siba, Ivo Mueller, Christopher L King, Francois Nosten, James G Beeson, Stephen Rogerson, Julie A Simpson, Freya JI Fowkes

2017-10-13

INTRODUCTION: During pregnancy, immunoglobulin G (IgG) is transferred from the mother to the fetus, providing protection from dise..

Scholarly works icon

A single point in protein trafficking by Plasmodium falciparum determines the expression of major antigens on the surface of infected erythrocytes targeted by human antibodies

Jo-Anne Chan, Katherine B Howell, Christine Langer, Alexander G Maier, Wina Hasang, Stephen J Rogerson, Michaela Petter, Joanne Chesson, Danielle I Stanisic, Michael F Duffy, Brian M Cooke, Peter M Siba, Ivo Mueller, Peter C Bull, Kevin Marsh, Freya JI Fowkes, James G Beeson

2016-11-01

Antibodies to blood-stage antigens of Plasmodium falciparum play a pivotal role in human immunity to malaria. During parasite deve..

Scholarly works icon

Decreasing Malaria Prevalence and Its Potential Consequences for Immunity in Pregnant Women

Andrew Teo, Wina Hasang, Louise M Randall, Gaoqian Feng, Lauren Bell, Holger Unger, Christine Langer, James G Beeson, Peter M Siba, Ivo Mueller, Malcolm E Molyneux, Graham V Brown, Stephen J Rogerson

2014-11-01

BACKGROUND: As malaria control is intensified, pregnant women may be less exposed to malaria, thus affecting the acquisition of pr..

Scholarly works icon

HIV-1 Infection and Antibodies to Plasmodium falciparum in Adults

Wina Hasang, Edson G Dembo, Rushika Wijesinghe, Malcolm E Molyneux, James G Kublin, Stephen Rogerson

2014-11-01

BACKGROUND: Coinfection with human immunodeficiency virus (HIV) may increase susceptibility to malaria by compromising naturally a..

Scholarly works icon

Targets of antibodies against Plasmodium falciparum-infected erythrocytes in malaria immunity

Jo-Anne Chan, Katherine B Howell, Linda Reiling, Ricardo Ataide, Claire L Mackintosh, Freya JI Fowkes, Michaela Petter, Joanne M Chesson, Christine Langer, George M Warimwe, Michael F Duffy, Stephen J Rogerson, Peter C Bull, Alan F Cowman, Kevin Marsh, James G Beeson

2012-09-01

Plasmodium falciparum is the major cause of malaria globally and is transmitted by mosquitoes. During parasitic development, P. fa..

University of Melbourne Researchers