SURFACE ANTIGENS AOF PLASMODIUM FALCIPARUM-INFECTED ERYTHOCYTES AND IMMUNITY TO MALARIA IN HUMANS
Grant number: 1047715 | Funding period: 2013 - 2015
Malaria is a leading cause of death globally, particularly among children. Malaria parasites infect red blood cells and multiply inside them, resulting in severe illness if left untreated. Effective treatments are limited and currently there is no vaccine. In human studies, we aim to identify the target antigens of immune responses and immune mechanisms that protect against malaria. With this knowledge, vaccines can be designed against malaria to prevent serious illness and death.
Related publications (5)
P. falciparum infection and maternofetal antibody transfer in malaria-endemic settings of varying transmission
Alistair RD McLean, Danielle Stanisic, Rose McGready, Kesinee Chotivanich, Caroline Clapham, Francesca Baiwog, Mupawjay Pimanpanarak, Peter Siba, Ivo Mueller, Christopher L King, Francois Nosten, James G Beeson, Stephen Rogerson, Julie A Simpson, Freya JI Fowkes
INTRODUCTION: During pregnancy, immunoglobulin G (IgG) is transferred from the mother to the fetus, providing protection from dise..
A single point in protein trafficking by Plasmodium falciparum determines the expression of major antigens on the surface of infected erythrocytes targeted by human antibodies
Jo-Anne Chan, Katherine B Howell, Christine Langer, Alexander G Maier, Wina Hasang, Stephen J Rogerson, Michaela Petter, Joanne Chesson, Danielle I Stanisic, Michael F Duffy, Brian M Cooke, Peter M Siba, Ivo Mueller, Peter C Bull, Kevin Marsh, Freya JI Fowkes, James G Beeson
Antibodies to blood-stage antigens of Plasmodium falciparum play a pivotal role in human immunity to malaria. During parasite deve..
Decreasing Malaria Prevalence and Its Potential Consequences for Immunity in Pregnant Women
Andrew Teo, Wina Hasang, Louise M Randall, Gaoqian Feng, Lauren Bell, Holger Unger, Christine Langer, James G Beeson, Peter M Siba, Ivo Mueller, Malcolm E Molyneux, Graham V Brown, Stephen J Rogerson
BACKGROUND: As malaria control is intensified, pregnant women may be less exposed to malaria, thus affecting the acquisition of pr..
HIV-1 Infection and Antibodies to Plasmodium falciparum in Adults
Wina Hasang, Edson G Dembo, Rushika Wijesinghe, Malcolm E Molyneux, James G Kublin, Stephen Rogerson
BACKGROUND: Coinfection with human immunodeficiency virus (HIV) may increase susceptibility to malaria by compromising naturally a..
Targets of antibodies against Plasmodium falciparum-infected erythrocytes in malaria immunity
Jo-Anne Chan, Katherine B Howell, Linda Reiling, Ricardo Ataide, Claire L Mackintosh, Freya JI Fowkes, Michaela Petter, Joanne M Chesson, Christine Langer, George M Warimwe, Michael F Duffy, Stephen J Rogerson, Peter C Bull, Alan F Cowman, Kevin Marsh, James G Beeson
Plasmodium falciparum is the major cause of malaria globally and is transmitted by mosquitoes. During parasitic development, P. fa..