ANNEXIN-A1 MIMETICS - NEW THERAPY FOR TREATING HEART ATTACK

Grant number: 1045140 | Funding period: 2013 - 2015

Completed

Abstract

Myocardial infarction (or heart attack, a result of reduced coronary blood flow) and subsequent heart failure are the major cause of death in Western societies; this is expanding to all corners of the globe. New treatments for heart attack are thus essential. We have discovered that the natural hormone annexin-A1 rescues heart muscle function over the short-term, and propose that drugs based on annexin-A1 will prevent cardiac dysfunction of heart muscle up to several weeks after heart attack.