Identifying key players in the spread of antimicrobial resistance
Grant number: 1043830 | Funding period: 2013 - 2015
Antibiotic drugs are essential to treat bacterial infections. However some bacteria have genes that allow them to resist certain drugs, which can be transferred among bacteria to create 'superbugs' that can resist nearly all the drugs we have. This project investigates the transfer of drug resistance genes between Gram negative bacteria (common agents of food poisoning, hospital infection, UTI, etc) and aims to identify the bacteria and genes most important in the spread of superbugs in Australia.
Related publications (2)
ISMapper: identifying transposase insertion sites in bacterial genomes from short read sequence data
Jane Hawkey, Mohammad Hamidian, Ryan R Wick, David J Edwards, Helen Billman-Jacobe, Ruth M Hall, Kathryn E Holt
BACKGROUND: Insertion sequences (IS) are small transposable elements, commonly found in bacterial genomes. Identifying the locatio..
SRST2: Rapid genomic surveillance for public health and hospital microbiology labs
Michael Inouye, Harriet Dashnow, Lesley-Ann Raven, Mark B Schultz, Bernard J Pope, Takehiro Tomita, Justin Zobel, Kathryn E Holt
Rapid molecular typing of bacterial pathogens is critical for public health epidemiology, surveillance and infection control, yet ..