Harnessing next-generation technologies to tackle major food-borne parasites and design new interventions

Transcriptional alterations in Caenorhabditis elegans following exposure to an anthelmintic fraction of the plant Picria fel-terrae Lour.

Rasika Kumarasingha, Neil D Young, Tiong-Chia Yeo, Diana SL Lim, Chu-Lee Tu, Enzo A Palombo, Jillian M Shaw, Robin B Gasser, Peter R Boag

2019-04-25

Background Natural compounds from plants are known to provide a source of anthelmintic molecules. In previous studies, we have sho..

Ascaris phylogeny based on multiple whole mtDNA genomes

Peter Nejsuma, Mohamed BF Hawash, Martha Betson, J Russell Stothard, Robin B Gasser, Lee O Andersen

2017-03-01

Ascaris lumbricoides and A. suum are two parasitic nematodes infecting humans and pigs, respectively. There has been considerable ..

The apicoplast genomes of two taxonomic units of Babesia from sheep

Tao Wang, Guiquan Guan, Pasi K Korhonen, Anson V Koehler, Ross S Hall, Neil D Young, Hong Yin, Robin B Gasser

2017-01-15

The apicoplast (ap) is a unique, non-photosynthetic organelle found in most apicomplexan parasites. Due to the essential roles tha..

Population structure of Haemonchus contortus from seven geographical regions in China, determined on the basis of microsatellite markers

Fangyuan Yin, Robin B Gasser, Facai Li, Min Bao, Weiyi Huang, Fengcai Zou, Guanghui Zhao, Chunren Wang, Xin Yang, Yanqin Zhou, Junlong Zhao, Rui Fang, Min Hu

2016-11-15

BACKGROUND: Studying genetic variation within and among Haemonchus contortus populations can inform some aspects of this parasite'..

Analyses of Compact Trichinella Kinomes Reveal a MOS-Like Protein Kinase with a Unique N-Terminal Domain

Andreas J Stroehlein, Neil D Young, Pasi K Korhonen, Bill CH Chang, Paul W Sternberg, Giuseppe La Rosa, Edoardo Pozio, Robin B Gasser

2016-09-01

Parasitic worms of the genus Trichinella (phylum Nematoda; class Enoplea) represent a complex of at least twelve taxa that infect ..

Detection of cryptic species of Rugopharynx (Nematoda: Strongylida) from the stomachs of Australian macropodid marsupials

Neil B Chilton, Florence Huby-Chilton, Anson V Koehler, Robin B Gasser, Ian Beveridge

2016-08-01

Sequences of the internal transcribed spacers of nuclear ribosomal DNA (ITS-1 and ITS-2) were determined for species of the genus ..

A perspective on genomic-guided anthelmintic discovery and repurposing using Haemonchus contortus

Sarah Preston, Abdul Jabbar, Robin B Gasser

2016-06-01

High-throughput molecular and computer technologies have become instrumental for systems biological explorations of parasites. Inv..

Phylogenomic and biogeographic reconstruction of the Trichinella complex

Pasi K Korhonen, Edoardo Pozio, Giuseppe La Rosa, Bill CH Chang, Anson V Koehler, Eric P Hoberg, Peter R Boag, Patrick Tan, Aaron R Jex, Andreas Hofmann, Paul W Sternberg, Neil D Young, Robin B Gasser

2016-02-01

Trichinellosis is a globally important food-borne parasitic disease of humans caused by roundworms of the Trichinella complex. Ext..

Practical and low cost whole-organism motility assay: A step-by-step protocol

Sarah Preston, Abdul Jabbar, Cameron Nowell, Anja Joachim, Baerbel Ruttkowski, Tony Cardno, Andreas Hofmann, Robin B Gasser

2016-02-01

Here, we provide a step-by-step protocol for a practical and low cost whole-organism assay for the screening of chemical compounds..

Assessment of the nematocidal activity of metallocenyl analogues of monepantel

Jeannine Hess, Malay Patra, Abdul Jabbar, Vanessa Pierroz, Sandro Konatschnig, Bernhard Spingler, Stefano Ferrari, Robin B Gasser, Gilles Gasser

2016-01-01

In this study, we present the design, synthesis, characterization and biological evaluation of structurally new ferrocenyl and rut..