Harnessing next-generation technologies to tackle major food-borne parasites and design new interventions
Grant number: LP130100208 | Funding period: 2014 - 2017
Frontier technologies will be used in this project to unlock the molecular secrets of parasites which cause serious food-borne diseases in animals. The quantum leap made here will lead to radically new ways of treating and controlling such diseases, and provide outstanding international visibility of Australian science and a solid skills/knowledge-base.
Related publications (10)
Transcriptional alterations in Caenorhabditis elegans following exposure to an anthelmintic fraction of the plant Picria fel-terrae Lour.
Rasika Kumarasingha, Neil D Young, Tiong-Chia Yeo, Diana SL Lim, Chu-Lee Tu, Enzo A Palombo, Jillian M Shaw, Robin B Gasser, Peter R Boag
Background Natural compounds from plants are known to provide a source of anthelmintic molecules. In previous studies, we have sho..
The apicoplast genomes of two taxonomic units of Babesia from sheep
Tao Wang, Guiquan Guan, Pasi K Korhonen, Anson V Koehler, Ross S Hall, Neil D Young, Hong Yin, Robin B Gasser
The apicoplast (ap) is a unique, non-photosynthetic organelle found in most apicomplexan parasites. Due to the essential roles tha..
Population structure of Haemonchus contortus from seven geographical regions in China, determined on the basis of microsatellite markers
Fangyuan Yin, Robin B Gasser, Facai Li, Min Bao, Weiyi Huang, Fengcai Zou, Guanghui Zhao, Chunren Wang, Xin Yang, Yanqin Zhou, Junlong Zhao, Rui Fang, Min Hu
BACKGROUND: Studying genetic variation within and among Haemonchus contortus populations can inform some aspects of this parasite'..
Analyses of Compact Trichinella Kinomes Reveal a MOS-Like Protein Kinase with a Unique N-Terminal Domain
Andreas J Stroehlein, Neil D Young, Pasi K Korhonen, Bill CH Chang, Paul W Sternberg, Giuseppe La Rosa, Edoardo Pozio, Robin B Gasser
Parasitic worms of the genus Trichinella (phylum Nematoda; class Enoplea) represent a complex of at least twelve taxa that infect ..
Detection of cryptic species of Rugopharynx (Nematoda: Strongylida) from the stomachs of Australian macropodid marsupials
Neil B Chilton, Florence Huby-Chilton, Anson V Koehler, Robin B Gasser, Ian Beveridge
Sequences of the internal transcribed spacers of nuclear ribosomal DNA (ITS-1 and ITS-2) were determined for species of the genus ..
Phylogenomic and biogeographic reconstruction of the Trichinella complex
Pasi K Korhonen, Edoardo Pozio, Giuseppe La Rosa, Bill CH Chang, Anson V Koehler, Eric P Hoberg, Peter R Boag, Patrick Tan, Aaron R Jex, Andreas Hofmann, Paul W Sternberg, Neil D Young, Robin B Gasser
Trichinellosis is a globally important food-borne parasitic disease of humans caused by roundworms of the Trichinella complex. Ext..
Practical and low cost whole-organism motility assay: A step-by-step protocol
Sarah Preston, Abdul Jabbar, Cameron Nowell, Anja Joachim, Baerbel Ruttkowski, Tony Cardno, Andreas Hofmann, Robin B Gasser
Here, we provide a step-by-step protocol for a practical and low cost whole-organism assay for the screening of chemical compounds..
Assessment of the nematocidal activity of metallocenyl analogues of monepantel
Jeannine Hess, Malay Patra, Abdul Jabbar, Vanessa Pierroz, Sandro Konatschnig, Bernhard Spingler, Stefano Ferrari, Robin B Gasser, Gilles Gasser
In this study, we present the design, synthesis, characterization and biological evaluation of structurally new ferrocenyl and rut..