CHRONIC TLR9 ACTIVATION AS A MECHANISM FOR GRANULOMATOUS REACTION IN THE CORNEA
Grant number: 1042612 | Funding period: 2013 - 2017
Corneal opacities due to microbial infections are a major cause of blindness globally. Our novel data show that the presence of viral/bacterial DNA in the cornea induces formation of multinucleated giant cells, which are hallmarks of granulomatous reaction commonly seen in viral-induced corneal disease. Understanding the mechanisms and kinetics of macrophage differentiation in the inflamed cornea may lead to novel treatments for chronic inflammatory conditions in the eye and in other organs.
Related publications (9)
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Optical coherence tomography (OCT) provides non-invasive, high-resolution in vivo imaging of the ocular surface and anterior segme..
Recovery of the sub-basal nerve plexus and superficial nerve terminals after corneal epithelial injury in mice
Laura E Downie, Cecilia Naranjo Golborne, Merry Chen, Ho Ngoc, Hoac Cam, Dasun Liyanapathirana, Carol Luo, Ruo Bing Wu, Holly R Chinnery
Our aim was to compare regeneration of the sub-basal nerve plexus (SBNP) and superficial nerve terminals (SNT) following corneal e..
Longitudinal Changes to Tight Junction Expression and Endothelial Cell Integrity in a Mouse Model of Sterile Corneal Inflammation
Laura E Downie, Janet Choi, Jeremiah KH Lim, Holly R Chinnery
PURPOSE: We previously reported that applying toll-like receptor (TLR) ligands to an injured cornea induces corneal edema at 24 ho..
Retinal Microglial Activation Following Topical Application of Intracellular Toll-Like Receptor Ligands
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PURPOSE: We previously have reported that application of the intracellular toll-like receptor (TLR)-9 ligand CpG-ODN onto the inju..
TLR9 and TLR7/8 activation induces formation of keratic precipitates and giant macrophages in the mouse cornea
Holly R Chinnery, Cheng Mee Leong, Weisan Chen, John V Forrester, Paul G McMenamin
Macrophage adherence to the inner corneal surface and formation of MGCs in the stroma are common signs of chronic inflammation fol..