Building Immunity to Breast Cancer With Radio-Immunotherapy Combinations

Abstract

For over a century radiotherapy has been used for the treatment of cancer. Employed for its powerful capacity to reduce tumor cell viability and induce cell-cycle arrest, radiotherapy has proven effective in curing a broad range of cancers. However, issues relating to the small window of differential sensitivity between normal tissue and tumor cells, radio-resistance and therapeutic failure have established grounds to examine the concomitant use of RT with established forms of immunotherapy. Incentive to explore such integrated approaches in clinical oncology has been driven by accumulating preclinical and clinical evidence that support the idea that immune mediated mechanisms can contribute..

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