TRANSLATING MOLECULAR INSIGHTS IN SQUAMOUS CELL CARCINOMA INTO NOVEL THERAPEUTICS
Grant number: 1049870 | Funding period: 2013 - 2016
In Australia, skin cancers account for 80% of all new cases of cancer, and over 95% of these are basal cell cancers (BCC) or squamous cell cancers (SCC). Although exposure to the sun is the major factor responsible for both of these cancers, it is not known what genes are damaged allowing them to grow in an uncontrolled manner. Our laboratory has identified critical genes that malfunction in SCC. This discovery will allow us to develop new preventative and curative strategies for SCC.
Related publications (3)
Loss of GRHL3 leads to TARC/CCL17-mediated keratinocyte proliferation in the epidermis
Stephen J Goldie, Denny L Cottle, Fiona H Tan, Suraya Roslan, Seema Srivastava, Rhys Brady, Darren D Partridge, Alana Auden, Ian M Smyth, Stephen M Jane, Sebastian Dworkin, Charbel Darido
Identifying soluble factors that influence epidermal integrity is critical for the development of preventative and therapeutic str..
Stage-dependent therapeutic efficacy in PI3K/mTOR-driven squamous cell carcinoma of the skin
Charbel Darido, Smitha R Georgy, Carleen Cullinane, Darren D Partridge, Rachael Walker, Seema Srivastava, Suraya Roslan, Marina R Carpinelli, Sebastian Dworkin, Richard B Pearson, Stephen M Jane
Cutaneous squamous cell carcinoma (SCC) is a recurrent cancer that is prevalent in predisposed subjects such as immunosuppressed p..