Dopamine, frontal-subcortical circuits and risk for schizophrenia
Grant number: 1050504 | Funding period: 2013 - 2016
Schizophrenia is a debilitating mental disorder characterized by psychotic experiences and emotional and cognitive difficulties. This project will map how disruptions of specific brain circuits relate to risk for schizophrenia and use genetic modeling techniques to understand how dysregulation of a specific chemical in the brain, dopamine, might cause these changes. This work will have important implications for developing new, more targeted treatments.
Related publications (1)
Lack of Evidence for Regional Brain Volume or Cortical Thickness Abnormalities in Youths at Clinical High Risk for Psychosis: Findings From the Longitudinal Youth at Risk Study
Paul Klauser, Juan Zhou, Joseph KW Lim, Joann S Poh, Hui Zheng, Han Ying Tng, Ranga Krishnan, Jimmy Lee, Richard SE Keefe, R Alison Adcock, Stephen J Wood, Alex Fornito, Michael WL Chee
There is cumulative evidence that young people in an "at-risk mental state" (ARMS) for psychosis show structural brain abnormaliti..