New players in urethral closure; defining the role of a novel long noncoding RNA

Grant number: 5R01DK096263 | Funding period: 2012 - 2018

Completed

Abstract

DESCRIPTION (provided by applicant): Hypospadias (the abnormal placement of the urethral opening) is one of the most common birth defects in the USA, affecting approximately 1 in every 140 live male births. Despite its high incidence, relatively little is known about the causes of this common disease. A few genes have been isolated that predispose the penis to hypospadias. However, genetic causes alone cannot explain a doubling in the reported rate of hypospadias in the USA between 1970-1993. Since inappropriate estrogen exposure or inhibition of androgen signaling have both been shown to induce hypospadias, its increase has been attributed to environmental factors, with environmental endocr..

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Related publications (8)

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Endocrine disrupting chemicals in the pathogenesis of hypospadias; developmental and toxicological perspectives

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Hypospadias is a defect in penile urethral closure that occurs in approximately 1/150 live male births in developed nations, makin..

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Atrazine induces penis abnormalities including hypospadias in mice

Luke C Govers, Alesia P Harper, Bethany J Finger, Deidre M Mattiske, Andrew J Pask, Mark P Green

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Use of the herbicide atrazine (ATR) is banned in the European Union; yet, it is still widely used in the USA and Australia. ATR is..

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A novel long non-coding RNA, Leat1, causes reduced anogenital distance and fertility in female mice

Deidre Mattiske, Richard R Behringer, Paul A Overbeek, Andrew J Pask

2020-03-01

Defective anorectal and urogenital malformations are some of the most severe congenital anomalies encountered in children. Only a ..

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A critical role for estrogen signaling in penis development

Luke C Govers, Tiffany R Phillips, Deidre M Mattiske, Nineveh Rashoo, Jay R Black, Adriane Sinclair, Laurence S Baskin, Gail P Risbridger, Andrew J Pask

2019-09-01

Hypospadias, a developmental defect of the penis, is one of the most common congenital malformations in humans. Its incidence has ..

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A loss of estrogen signaling in the aromatase deficient mouse penis results in mild hypospadias

Samuel M Cripps, Deidre M Mattiske, Jay R Black, Gail P Risbridger, Luke C Govers, Tiffany R Phillips, Andrew J Pask

2019-09-01

Hypospadias is the abnormal opening of the urethra on the underside of the penis and occurs in approximately 1/125 live male birth..

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Flutamide-induced hypospadias in rats: A critical assessment

Adriane Watkins Sinclair, Mei Cao, Andrew Pask, Laurence Baskin, Gerald R Cunha

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This paper provides the first detailed description of flutamide-induced hypospadias in the rat based upon wholemount, histologic, ..

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A Comprehensive Atlas of the Adult Mouse Penis

A PASK, TR Phillips, DK Wright, PE Gradie, LA Johnston

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Mice are routinely used to study the development of the external genitalia and, in particular, the process of male urethral closur..

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The Genetic and Environmental Factors Underlying Hypospadias

Aurore Bouty, Katie L Ayers, Andrew Pask, Yves Heloury, Andrew H Sinclair

2015-01-01

Hypospadias results from a failure of urethral closure in the male phallus and affects 1 in 200-300 boys. It is thought to be due ..

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