CELL BIOLOGY OF MALARIA PARASITES

Grant number: 1062504 | Funding period: 2014 - 2017

Completed

Abstract

I am a molecular biologist and bioinformatician studying the cell biology of human parasites. I have expertise in the bioinformatic analysis of parasite genomes to predict where proteins will reside in cell, how they participate in metabolic pathways, and how they might be suitable as targets for drugs and vaccines to control parasitic diseases. This fellowship will investigate the cell biology of Plasmodium parasites, the causative agents of malaria, using computational and biochemical tools to characterise drug and vaccine targets.

Related publications (8)

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Alternative splicing is required for stage differentiation in malaria parasites

Lee M Yeoh, Christopher D Goodman, Vanessa Mollard, Emma McHugh, V Vern Lee, Angelika Sturm, Anton Cozijnsen, Geoffrey I McFadden, Stuart A Ralph

2019-08-01

BACKGROUND: In multicellular organisms, alternative splicing is central to tissue differentiation and identity. Unicellular protis..

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Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking

Kit Kennedy, Simon A Cobbold, Eric Hanssen, Jakob Birnbaum, Natalie J Spillman, Emma McHugh, Hannah Brown, Leann Tilley, Tobias Spielmann, Malcolm J McConville, Stuart A Ralph

2019-07-18

Apicomplexan parasites possess a plastid organelle called the apicoplast. Inhibitors that selectively target apicoplast housekeepi..

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Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates

Lee M Yeoh, Christopher D Goodman, Vanessa Mollard, Geoffrey I McFadden, Stuart A Ralph

2017-09-18

BACKGROUND: The clinical symptoms of malaria are caused by the asexual replication of Plasmodium parasites in the blood of the ver..

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Metabolomics-Based Screening of the Malaria Box Reveals both Novel and Established Mechanisms of Action

Darren J Creek, Hwa H Chua, Simon A Cobbold, Brunda Nijagal, James I MacRae, Benjamin K Dickerman, Paul R Gilson, Stuart A Ralph, Malcolm J McConville

2016-11-01

High-throughput phenotypic screening of chemical libraries has resulted in the identification of thousands of compounds with poten..

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Large scale production of a mammalian cell derived quadrivalent hepatitis C virus like particle vaccine

L Earnest-Silveira, D Christiansen, S Herrmann, SA Ralph, S Das, EJ Gowans, J Torresi

2016-10-01

A method for the large-scale production of a quadrivalent mammalian cell derived hepatitis C virus-like particles (HCV VLPs) is de..

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Selective inhibition of apicoplast tryptophanyl-tRNA synthetase causes delayed death in Plasmodium falciparum

Charisse Flerida A Pasaje, Vanessa Cheung, Kit Kennedy, Erin E Lim, Jonathan B Baell, Michael DW Griffin, Stuart A Ralph

2016-06-09

The malaria parasite Plasmodium falciparum relies on efficient protein translation. An essential component of translation is the t..

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Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase is a potential drug target

Stacey M Allen, Erin E Lim, Esther Jortzik, Janina Preuss, Hwa Huat Chua, James I MacRae, Stefan Rahlfs, Kristina Haeussler, Matthew T Downton, Malcolm J McConville, Katja Becker, Stuart A Ralph

2015-10-01

The malarial parasite Plasmodium falciparum is exposed to substantial redox challenges during its complex life cycle. In intraeryt..

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Targeting and function of proteins mediating translation initiation in organelles of Plasmodium falciparum

Afreen Haider, Stacey M Allen, Katherine E Jackson, Stuart A Ralph, Saman Habib

2015-05-01

The malaria parasite Plasmodium falciparum has two translationally active organelles - the apicoplast and mitochondrion, which imp..

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