FIGHTING EMERGING ANTIMALARIAL DRUG RESISTANCE

Grant number: 1060357 | Funding period: 2014 - 2017

Completed

Abstract

Artemisinin-based antimalarials (ARTs) save hundreds of thousands of lives every year. Unfortunately resistance of P. falciparum to ART is now emerging in South East Asia and it is critical to know how and why. We will determine what is different about resistant parasites and will develop assays to monitor drug resistance in the field. We have found that the immature form of the malaria parasite is more resistant to ARTs, which helps explain resistance. We will build on this to develop new targetted treatments.

Related publications (5)

Scholarly works icon

Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome

Jessica L Bridgford, Stanley C Xie, Simon A Cobbold, Charisse Flerida A Pasaje, Susann Herrmann, Tuo Yang, David L Gillett, Lawrence R Dick, Stuart A Ralph, Con Dogovski, Natalie J Spillman, Leann Tilley

2018-09-18

Artemisinin and its derivatives (collectively referred to as ARTs) rapidly reduce the parasite burden in Plasmodium falciparum inf..

Scholarly works icon

A Dynamic Stress Model Explains the Delayed Drug Effect in Artemisinin Treatment of Plasmodium falciparum

Pengxing Cao, Nectarios Klonis, Sophie Zaloumis, Con Dogovski, Stanley C Xie, Sompob Saralamba, Lisa J White, Freya JI Fowkes, Leann Tilley, Julie A Simpson, James M McCaw

2017-12-01

Artemisinin resistance constitutes a major threat to the continued success of control programs for malaria, particularly in light ..

Scholarly works icon

A mechanistic model quantifies artemisinin-induced parasite growth retardation in blood-stage Plasmodium falciparum infection

Pengxing Cao, Nectarios Klonis, Sophie Zaloumis, David S Khoury, Deborah Cromer, Miles P Davenport, Leann Tilley, Julie A Simpson, James M McCaw

2017-10-07

Falciparum malaria is a major parasitic disease causing widespread morbidity and mortality globally. Artemisinin derivatives-the m..

Scholarly works icon

Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strains

Tuo Yang, Stanley C Xie, Pengxing Cao, Carlo Giannangelo, James McCaw, Darren J Creek, Susan A Charman, Nectarios Klonis, Leann Tilley

2016-08-01

Fully synthetic endoperoxide antimalarials, namely, OZ277 (RBx11160; also known as arterolane) and OZ439 (artefenomel), have been ..

Scholarly works icon

Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins

Stanley C Xie, Con Dogovski, Eric Hanssen, Francis Chiu, Tuo Yang, Maria P Crespo, Che Stafford, Steven Batinovic, Silvia Teguh, Susan Charman, Nectarios Klonis, Leann Tilley

2016-01-15

Current first-line artemisinin antimalarials are threatened by the emergence of resistant Plasmodium falciparum. Decreased sensiti..

University of Melbourne Researchers