DISSECTING THE MOLECULAR BASIS OF LEISHMANIA PATHOGENESIS
Grant number: 1059545 | Funding period: 2014 - 2017
Our lack of understanding of microbial metabolism in infected animal tissues has hindered the development of effective therapies. This is particularly true for many parasitic diseases, including Leishmania spp that cause devastating disease throughout the tropics. We will utilize a range of innovative analytical and genetic approaches to identify metabolic pathway in Leishmania parasites and infected host cells that are required for virulence and are potential drug targets.
Related publications (4)
Leishmania mexicana can utilize amino acids as major carbon sources in macrophages but not in animal models
Eleanor C Saunders, Thomas Naderer, Jenny Chambers, Scott M Landfear, Malcolm J McConville
Leishmania parasites target macrophages in their mammalian hosts and proliferate within the mature phagolysosome compartment of th..
Characterization of Metabolically Quiescent Leishmania Parasites in Murine Lesions Using Heavy Water Labeling
Joachim Kloehn, Eleanor C Saunders, Sean O'Callaghan, Michael J Dagley, Malcolm J McConville
Information on the growth rate and metabolism of microbial pathogens that cause long-term chronic infections is limited, reflectin..
Golgi-Located NTPDase1 of Leishmania major Is Required for Lipophosphoglycan Elongation and Normal Lesion Development whereas Secreted NTPDase2 Is Dispensable for Virulence
Fiona M Sansom, Julie E Ralton, M Fleur Sernee, Alice M Cohen, David J Hooker, Elizabeth L Hartland, Thomas Naderer, Malcolm J McConville
Parasitic protozoa, such as Leishmania species, are thought to express a number of surface and secreted nucleoside triphosphate di..