IMMUNE FUNCTIONS IN PERIPHERAL TISSUES
Grant number: 1059514 | Funding period: 2014 - 2016
Protection from infections relies on different types of immune cells. While some of these cells are found in the blood, others reside in peripheral tissues such as the skin. We will analyse the function of these peripheral immune cells to understand how they work to fight off infections. We will also investigate how so-called memory cells that permanently reside in peripheral tissues can protect from re-infection with similar bacteria or viruses.
Related publications (4)
Ptpn2 and KLRG1 regulate the generation and in skin
Katharina Hochheiser, Florian Wiede, Teagan Wagner, David Freestone, Matthias H Enders, Moshe Olshansky, Brendan Russ, Simone Nussing, Emma Bawden, Asolina Braun, Annabell Bachem, Elise Gressier, Robyn McConville, Simone L Park, Claerwen M Jones, Gayle M Davey, David E Gyorki, David Tscharke, Ian A Parish, Stephen Turner
Tissue-resident memory T cells (TRM cells) are key elements of tissue immunity. Here, we investigated the role of the regulator of..
Tissue-resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance
Thomas Gebhardt, Umaimainthan Palendira, David C Tscharke, Sammy Bedoui
A large proportion of memory T cells disseminated throughout the body are non-recirculating cells whose maintenance and function i..
Effective Priming of Herpes Simplex Virus-Specific CD8( ) T Cells In Vivo Does Not Require Infected Dendritic Cells
Paul G Whitney, Christina Makhlouf, Beth MacLeod, Joel Z Ma, Elise Gressier, Marie Greyer, Katharina Hochheiser, Annabell Bachem, Ali Zaid, David Voehringer, William R Heath, Mayura V Wagle, Ian Parish, Tiffany A Russell, Stewart A Smith, David C Tscharke, Thomas Gebhardt, Sammy Bedoui
Resolution of virus infections depends on the priming of virus-specific CD8+ T cells by dendritic cells (DC). While this process r..
Distinct APC Subtypes Drive Spatially Segregated CD4 and CD8 T-Cell Effector Activity during Skin Infection with HSV-1
Bethany L Macleod, Sammy Bedoui, Jyh Liang Hor, Scott N Mueller, Tiffany A Russell, Natasha A Hollett, William R Heath, David C Tscharke, Andrew G Brooks, Thomas Gebhardt
Efficient infection control requires potent T-cell responses at sites of pathogen replication. However, the regulation of T-cell e..