ROLE OF ANGIOTENSIN HORMONES IN LIVER DISEASE

Grant number: 1062372 | Funding period: 2014 - 2016

Completed

Abstract

Cirrhosis of the liver due to chronic hepatitis and other common liver diseases is now a major cause of illness and death in Australia. This project will examine how a hormone system called the renin angiotensin system contributes to the development of liver damage in these diseases. We will study whether drugs targeting this system can be used to reduce liver scarring and prevent the development of cirrhosis and its complications.

Related publications (4)

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Liver-Targeted Angiotensin Converting Enzyme 2 Therapy Inhibits Chronic Biliary Fibrosis in Multiple Drug-Resistant Gene 2-Knockout Mice

Indu G Rajapaksha, Lakmie S Gunarathne, Khashayar Asadi, Sharon C Cunningham, Alexandra Sharland, Ian E Alexander, Peter W Angus, Chandana B Herath

2019-12-01

There is a large unmet need for effective therapies for cholestatic disorders, including primary sclerosing cholangitis (PSC), a d..

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Activation of the Alternate Renin-Angiotensin System Correlates with the Clinical Status in Human Cirrhosis and Corrects Post Liver Transplantation

Stephen Casey, Robert Schierwagen, Kai Yan Mak, Sabine Klein, Frank Uschner, Christian Jansen, Michael Praktiknjo, Carsten Meyer, Daniel Thomas, Chandana Herath, Robert Jones, Jonel Trebicka, Peter Angus

2019-04-01

INTRODUCTION: Recent animal studies have shown that the alternate renin-angiotensin system (RAS) consisting of angiotensin-convert..

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The small molecule drug diminazene aceturate inhibits liver injury and biliary fibrosis in mice

Indu G Rajapaksha, Kai Y Mak, Ping Huang, Louise M Burrell, Peter W Angus, Chandana B Herath

2018-07-05

There is no established medical therapy to treat biliary fibrosis resulting from chronic inflammation in the biliary tree. We have..

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Role of the Alternate RAS in Liver Disease and the GI Tract

CB Herath, KY Mak, PW Angus

2015-04-22

Recent findings suggesting antifibrotic and vasodilatory functions of the alternate arm of the renin-angiotensin system (RAS) in l..

University of Melbourne Researchers