A Treatment Planning System to Enable Clinical Trials of Synchrotron Radiotherapy

Grant number: 1061772 | Funding period: 2014 - 2014

Completed

Abstract

Microbeam Radiotherapy (MRT) using synchrotron-generated X-rays has shown tremendous promise in pre-clinical trials in tumour-bearing rodents, with remarkable sparing of normal tissue. Synchrotron MRT has the potential to radically alter the way radiotherapy is performed for human cancers. Every radiotherapy patient undergoes some form of computerised treatment planning before their treatment starts. We aim to test and implement a synchrotron Treatment Planning System, as an essential step in realising synchrotron radiotherapy trials.

Related publications (7)

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The γH2AX DSB marker may not be a suitable biodosimeter to measure the biological MRT valley dose

JA Ventura, JF Donoghue, CJ Nowell, LM Cann, LRJ Day, LML Smyth, HB Forrester, PAW Rogers, JC Crosbie

2021-01-01

Purpose: γH2AX biodosimetry has been proposed as an alternative dosimetry method for microbeam radiation therapy (MRT) because con..

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A Monte Carlo model of synchrotron radiotherapy shows good agreement with experimental dosimetry measurements: Data from the imaging and medical beamline at the Australian Synchrotron

LRJ Day, P Pellicioli, F Gagliardi, M Barnes, LML Smyth, D Butler, J Livingstone, AW Stevenson, J Lye, CM Poole, D Hausermann, PAW Rogers, JC Crosbie

2020-09-01

Experimental measurement of Synchrotron Radiotherapy (SyncRT) doses is challenging, especially for Microbeam Radiotherapy (MRT), w..

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Identifying optimal clinical scenarios for synchrotron microbeam radiation therapy: A treatment planning study

LML Smyth, LR Day, K Woodford, PAW Rogers, JC Crosbie, S Senthi

2019-04-01

Purpose: Synchrotron Microbeam Radiation Therapy (MRT) is a pre-clinical modality characterised by spatial dose fractionation on a..

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Comparative toxicity of synchrotron and conventional radiation therapy based on total and partial body irradiation in a murine model

LML Smyth, JF Donoghue, JA Ventura, J Livingstone, T Bailey, LRJ Day, JC Crosbie, PAW Rogers

2018-12-01

Synchrotron radiation can facilitate novel radiation therapy modalities such as microbeam radiation therapy (MRT) and high dose-ra..

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Characterization of Diffuse Intrinsic Pontine Glioma Radiosensitivity using Synchrotron Microbeam Radiotherapy and Conventional Radiation Therapy in Vitro

LM Smyth, PAW Rogers, JC Crosbie, JF Donoghue

2018-02-01

Synchrotron microbeam radiation therapy is a promising preclinical radiotherapy modality that has been proposed as an alternative ..

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Synchrotron microbeam radiotherapy in a commercially available treatment planning system

C MPoole, LRJ Day, PAW Rogers, JC Crosbie

2017-02-21

In this paperwe use a research licensed version of the Eclipse TM treatment planning system (TPS) from Varian Medical Systems, Inc..

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The normal tissue effects of microbeam radiotherapy: What do we know, and what do we need to know to plan a human clinical trial?

LML Smyth, S Senthi, JC Crosbie, PAW Rogers

2016-06-02

Purpose Microbeam Radiotherapy (MRT) is a promising pre-clinical cancer therapy which represents a radical departure from the radi..

University of Melbourne Researchers