How The Malaria Parasite And The Host Response To The Parasite Combine To Increase Risk Of Severe Malaria
Grant number: 1061993 | Funding period: 2014 - 2016
One factor that determines whether some children die of malaria is the type of protein that the parasite expresses on the red blood cell, to help it stick in blood vessels. Our new data suggests that some proteins stimulate excessive host immune response, possibly leading to severe malaria. People's immne response to malaria varies too, and we will discover whether severe malaria occurs when a dangerous parasite strain infects a susceptible host causing an excessive immune response, harming the child.
Related publications (5)
Malawian children with uncomplicated and cerebral malaria have decreased activated V gamma 9V delta 2 gamma delta T cells which increase in convalescence
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Malaria is responsible for almost half a million deaths annually. The role of Vγ9Vδ2 γδ T cells in malaria is still unclear. Studi..
Meta-analysis of Plasmodium falciparum var Signatures Contributing to Severe Malaria in African Children and Indian Adults
Fergal Duffy, Maria Bernabeu, Prasad H Babar, Anne Kessler, Christian W Wang, Marina Vaz, Laura Chery, Wilson L Mandala, Stephen J Rogerson, Terrie E Taylor, Karl B Seydel, Thomas Lavstsen, Edwin Gomes, Kami Kim, John Lusingu, Pradipsinh K Rathod, John D Aitchison, Joseph D Smith
The clinical presentation of severe Plasmodium falciparum malaria differs between children and adults, but the mechanistic basis f..
Linking EPCR-Binding PfEMP1 to Brain Swelling in Pediatric Cerebral Malaria
Anne Kessler, Selasi Dankwa, Maria Bernabeu, Visopo Harawa, Samuel A Danziger, Fergal Duffy, Sam D Kampondeni, Michael J Potchen, Nicholas Dambrauskas, Vladimir Vigdorovich, Brian G Oliver, Sarah E Hochman, Wenzhu B Mowrey, Ian JC MacCormick, Wilson L Mandala, Stephen J Rogerson, D Noah Sather, John D Aitchison, Terrie E Taylor, Karl B Seydel
CD14(hi)CD16 monocytes phagocytose antibody-opsonised Plasmodium falciparum infected erythrocytes more efficiently than other monocyte subsets, and require CD16 and complement to do so
Jingling Zhou, Gaoqian Feng, James Beeson, P Mark Hogarth, Stephen J Rogerson, Yan Yan, Anthony Jaworowski
Background With more than 600,000 deaths from malaria, mainly of children under five years old and caused by infection with Plasmo..