How The Malaria Parasite And The Host Response To The Parasite Combine To Increase Risk Of Severe Malaria

Grant number: 1061993 | Funding period: 2014 - 2016

Completed

Abstract

One factor that determines whether some children die of malaria is the type of protein that the parasite expresses on the red blood cell, to help it stick in blood vessels. Our new data suggests that some proteins stimulate excessive host immune response, possibly leading to severe malaria. People's immne response to malaria varies too, and we will discover whether severe malaria occurs when a dangerous parasite strain infects a susceptible host causing an excessive immune response, harming the child.

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